This observational study aims to understand liver health in adults with Fontan circulation and those with right heart failure. Researchers are using a special test called the HepQuant dual cholate clearance assay, which measures how well your liver is working. You would receive labeled oral and intravenous cholate, followed by two blood samples over 60 minutes. The study also involves a cardiac MRI (Magnetic Resonance Imaging) scan. The goal is to see if this cholate clearance test can accurately measure liver function in these conditions and predict future health outcomes. You may be eligible if you are an adult (18+) with Fontan circulation who has had a right heart catheterization recently, or a non-Fontan adult with two heart chambers, good left heart function, and a specific CVP estimate. The study plans to enroll 75 participants.

Study design

This is an observational study, meaning researchers will collect information without giving new treatments. It aims to enroll 75 participants.

What's involved

You would undergo a HepQuant dual cholate clearance assay (oral and intravenous cholate, two blood samples) and a cardiac MRI at the start. Your health status will then be tracked for 5 years.

Compensation

Not stated in the trial record.

Follow-up

Participants will have their health status collected for 5 years after the initial procedures.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.