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Brain Stimulation to the Hippocampus in Schizophrenia

This study is exploring whether brain stimulation can affect activity in the hippocampus (a part of the brain important for memory and emotion) in people with schizophrenia. Researchers will use either intracranial electrodes (wires placed inside the brain) or transcranial magnetic stimulation (TMS), which uses magnetic fields outside the head, to deliver electrical brain stimulation. A sham TMS (a fake treatment) will also be used for comparison. The study aims to understand if these methods can change brain activity, measured by EEG (a test that records brain waves), after one treatment session. You may be able to join if you are 18-65 years old and have medically intractable epilepsy (for the intracranial electrode arm) or a schizophrenia spectrum disorder (for the TMS arm). The study plans to enroll 60 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 60 participants. It will compare different types of brain stimulation, including a sham (inactive) treatment.
What's involved
The study will measure changes in brain activity using EEG after one brain stimulation session, specifically 45 minutes after the session.
Compensation
Not stated in the trial record.
Follow-up
Changes in brain activity will be measured 45 minutes after a single treatment session. It is not specified if there is follow-up beyond this.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07010614

Brain Stimulation to the Hippocampus in Schizophrenia

Recruiting
NAAges 18–65InterventionalBasic science
Stanford University
~60 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:Intracranial electrodesTMSTMS sham

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in intracranial EEG after one TBS session
Measured over 45 minutes
+1 more outcome measured

Conditions

Schizophrenia Disorders
Mental Disorder
Psychotic Disorder

Explore related trials

Brief Psychotic DisorderDelusional DisorderSchizoaffective DisorderSchizophreniaSchizophreniform DisorderSeizure Disorder

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Ethan A Solomon, MD, PhD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

Study Team
[email protected]
408-840-3313
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Men and women, ages 18 to 65 years
Medically intractable epilepsy requiring phase II monitoring (intracranial EEG arms only)
DSM-V diagnosis of schizophrenia spectrum Axis I disorders including delusional disorder, brief psychotic disorder, schizophreniform disorder, schizophrenia, schizoaffective disorder (non-invasive TMS-EEG arms only).
Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
No current or history of major neurological disorders other than epilepsy.

Exclusion

DSM5 diagnosis of intellectual disability
Significant head injury
Active suicidal ideation or history of suicide attempt within the past 1 year.
Medical illness affecting brain structure or function, or other uncontrolled or unstable medical condition.
Pregnancy or postpartum (\<6 weeks after delivery or miscarriage)
Inability to provide informed consent
Active substance abuse other than alcohol or cannabis within the past 1 year
Psychotic illness with a temporal relation to substance use or head injury
Those with a contraindication for MRIs or TMS (e.g. implanted metal).

What this trial measures

  • Change in intracranial EEG after one TBS session45 minutes

    Change in spontaneous oscillatory EEG power from before to after application of one TBS session, for active and sham stimulation, as measured via intracranial recording electrodes (iEEG).

  • Change in scalp EEG after one TBS session45 minutes

    Change in spontaneous oscillatory EEG power from before to after application of one TBS session, for active and sham stimulation, as measured via scalp recording electrodes (scalp electroencephalography).