Testing HARPP for PTSD and Obesity in Veterans

This study is testing an integrated treatment called HARPP for Veterans who have both Post-Traumatic Stress Disorder (PTSD) and obesity. HARPP combines a weight management program (MOVE!) with a type of therapy for PTSD called Cognitive Processing Therapy (CPT). Researchers want to see if HARPP is more effective at helping Veterans lose weight and reduce their PTSD symptoms compared to standard care, which involves separate referrals to MOVE! and CPT. The study plans to enroll 182 adult Veterans who have a current PTSD diagnosis and a BMI of 30 kg/m2 or higher. Success will be measured by changes in weight and PTSD symptom severity after 12 months. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 182 adult Veterans. Participants will be assigned to either receive the HARPP intervention or a control arm receiving standard care.
What's involved
Participants will receive up to 16 individual psychotherapy sessions as part of the HARPP intervention or standard CPT sessions in the control group. Weight and PTSD symptoms will be measured at 12 months after starting the study.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after starting the study to measure changes in weight and PTSD symptoms.

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NCT07010757

Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

Recruiting
NAAges 18+InterventionalTreatment
VA Office of Research and Development
~182 participants
Updated 2026-03-18 on ClinicalTrials.gov
What's tested:HARPPcontrol arm for HARPP trial

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
12-month absolute weight change in pounds
Measured over 12 months post-baseline
+1 more outcome measured
PTSD
Obesity
1 sites across 1 states
Washington1
  • Katherine D Hoerster, PhD MPH BA · PRINCIPAL_INVESTIGATOR · VA Puget Sound Health Care System Seattle Division, Seattle, WA

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  • 12-month absolute weight change in pounds12 months post-baseline

    Body weight will be measured on a study scale at baseline and 12 months following baseline. This study's co-primary aim is to test whether intervention participants have greater 12-month weight loss, relative to controls.

  • 12-month absolute PTSD symptom severity change12 months post-baseline

    PTSD symptom severity will be measured via self-report on the PTSD Checklist for DSM-5 at baseline and 12 months following baseline. This study's co-primary aim is to test whether intervention participants have greater 12-month PTSD symptom reduction, relative to controls.