Precision Analytic Research Methods in OCD

This study is looking for 100 English-speaking, right-handed adults aged 18-55, including 50 people with Obsessive Compulsive Disorder (OCD) and 50 healthy individuals. The goal is to better understand the complex brain processes involved in compulsivity, which is a key feature of OCD. You would receive Exposure and Response Prevention (EX/RP), a standard behavioral treatment for OCD. Researchers will use advanced computational modeling and electroencephalogram (EEG), which measures brain activity, to study how your brain works. The main way they will measure success is by tracking changes in your Yale Brown Obsessive Compulsive Scale scores at Week 1, Week 5, and Week 10. The study's current status is unclear.

Study design
This interventional study plans to enroll 100 participants, including 50 adults with OCD and 50 healthy controls. It is not specified if the study is randomized or blinded.
What's involved
You would receive Exposure and Response Prevention (EX/RP) treatment. Your Yale Brown Obsessive Compulsive Scale scores will be measured at Week 1, Week 5, and Week 10.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed for at least 10 weeks, with measurements taken at Week 1, Week 5, and Week 10.

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NCT07011901

Precision Analytic Research Methods in OCD

Recruiting
NAAges 18–55InterventionalTreatment
Icahn School of Medicine at Mount Sinai
~100 participants
Updated 2025-10-23 on ClinicalTrials.gov
What's tested:Exposure and Response Prevention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Yale Brown Obsessive Compulsive Scale
Measured over Week 1, Week 5, Week 10
Obsessive Compulsive Disorder
1 sites across 1 states
New York1
  • Amy Rapp, PhD · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

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Eligibility criteria

Inclusion

between the ages 18-55 years old
English-speaking
right-handed
able to provide consent

Exclusion

they meet diagnostic criteria for certain other psychiatric disorders
are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
if it is unsafe for them to participate in research
they have a current psychiatric disorder
a lifetime history of certain psychiatric disorders
are taking psychiatric medication or have in the past
have a parent or sibling who has been diagnosed with OCD
if it is unsafe for them to participate in research
  • Yale Brown Obsessive Compulsive ScaleWeek 1, Week 5, Week 10

    A semi-structured clinician-administered instrument used to measure obsessions and compulsions separately over five dimensions (time consumed, distress, interference, degree of resistance, control). The range of scores for the Obsessions and Compulsions subscales is 0-20, and the range for the total score is 0-40. Higher scores indicate greater symptom severity, and a total score greater or equal to 16 is considered indicative of moderately severe OCD