Ultralow Dose PET Imaging for Alzheimer's and Dementia
This study is testing a new way to use PET scans (Positron Emission Tomography, a type of imaging test) for Alzheimer's disease, mild cognitive impairment, and other dementias. Researchers want to see if they can use much lower doses of a special tracer called 18F-Florbetapir or 18F-Flutemetamol and still get clear images. These tracers help detect amyloid plaques, which are often found in Alzheimer's. The goal is to make these scans safer by reducing radiation exposure by 10 to 100 times. This could allow for more frequent screening and monitoring. The study plans to enroll 200 participants, including healthy volunteers and those with Alzheimer's, mild cognitive impairment, or dementia, aged 18 to 120 years old.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment or intervention. It aims to enroll 200 participants.
- What's involved
- You would receive an injection of 18F-Florbetapir or 18F-Flutemetamol and then have a PET scan for up to 3 hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study's success will be evaluated annually based on pooled images.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Signal-to-Noise Ratio (SNR)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Measurement of signal-to-noise ratio for image quality assessment across different scan durations, reconstruction techniques, and artificial intelligence (AI)-enhanced image reconstructions. Unit of Measure: SNR (unitless, numeric ratio)
- Contrast-to-Noise Ratio (CNR)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Measurement of contrast-to-noise ratio for image quality assessment across different scan durations, reconstruction techniques, and AI-enhanced image reconstructions. Unit of Measure: CNR (unitless, numeric ratio)
- Coefficient of Variation (COV)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Measurement of the coefficient of variation in selected regions for evaluating image consistency across different scan durations, reconstruction techniques, and AI-enhanced image reconstructions. Unit of Measure: Percentage (%)
- Spatial Resolution (Full Width at Half Maximum - FWHM)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Assessment of spatial resolution using full width at half maximum (FWHM) across different scan durations, reconstruction techniques, and AI-enhanced image reconstructions. Unit of Measure: Millimeters (mm)
- Target-to-Background Ratio (TBR)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Assessment of target-to-background ratio for evaluating PSMA-expressing tissue contrast across different scan durations, reconstruction techniques, and AI-enhanced image reconstructions. Unit of Measure: Ratio (unitless numeric ratio)
- Qualitative Image Quality Score (Likert Scale)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Independent qualitative evaluation of overall image quality, lesion detectability, image noise, and artifacts by nuclear medicine physicians, assessed using a 5-point Likert scale. Unit of Measure: Score on Likert Scale (1-5; 1 = worst, 5 = best)
- Inter-reader Agreement (Weighted Kappa Statistics)Evaluated annually (once per year), based on pooled images acquired during the preceding 12-month period.
Measurement of agreement among readers evaluating qualitative image quality scores, analyzed using weighted kappa statistics. Unit of Measure: Weighted kappa statistic (numeric value ranging from 0 to 1, 0 = no agreement, 1 = perfect agreement)