NCT07015528
Assessment of Drug Liking In Peri-procedural Clinical Settings
Enrolling by Invitation
EARLY_PHASE1Ages 18+InterventionalStanford UniversityInvestigator-initiated
~130 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:DroperidolPlacebo
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Drug Liking Rating
Measured over One minute before and 1, 3, and 5 minutes after fentanyl administration
Conditions
Where it's being run
1 sites across 1 statesCalifornia1
Study leadership
- Patrick L Purdon, PhD · PRINCIPAL_INVESTIGATOR · Stanford University
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
American Society of Anesthesiologists (ASA) physical status classification of I, II or III
Candidates who are expected to receive fentanyl up to 3 mcg/kg IBW for their scheduled for surgery or procedure
Exclusion
Craniofacial abnormalities
Known or suspected difficult intubation or mask ventilation
Known or suspected need for rapid sequence induction and intubation
Allergies or hypersensitivities to droperidol or fentanyl
Clinically significant pulmonary disease, such as chronic obstructive lung disease requiring long-term oxygen therapy, or other conditions that, in the study team's judgment, may increase the risk of severe respiratory depression with opioid administration
History of long QT syndrome
History of Torsades de Pointes
History of psychosis
History of movement disorders e.g. Parkinson's Disease
Past chronic use of anti-psychotics
Current use of droperidol, levodopa, lithium, clozapine, metoclopramide, benzodiazepines
Current use of opioids
History of opiate abuse within the last 3 years
Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
History of pheochromocytoma
History of concomitant prolactin-dependent tumors e.g. prolactinoma, breast cancer
Pregnancy or nursing
Current use of antiemetic medication (i.e., 5HT or dopamine antagonists)
Active seizure disorder
Active mental health disorders resulting in functional impairment
Current use of psychostimulant medications (Adderall)
Current use of CNS depressants (e.g., barbiturates, benzodiazepines)
Severe renal insufficiency (Stage 4 or 5)
Impaired cognitive function
Regular Cannabis use (2+ times per week)
Current history of substance abuse disorder.
Failure to satisfy the investigator of fitness to participate for any other reason
What this trial measures
- Change in Drug Liking RatingOne minute before and 1, 3, and 5 minutes after fentanyl administration
Change in drug liking rating (0-100), anchored by divert "not at all=0" and "as much as possible=100".