Light Therapy for Chemotherapy-Induced Peripheral Neuropathy in Childhood Cancer Survivors

This study is looking at whether a light therapy device called the Anodyne Therapy System can help childhood cancer survivors who have Chemotherapy-Induced Peripheral Neuropathy (CIPN). CIPN is nerve damage caused by chemotherapy, which can lead to pain, numbness, or tingling. The study aims to see if this at-home light therapy is practical and acceptable for survivors to use. You might be able to join if you had cancer as a child (diagnosed before age 21), are currently five years or older, received certain types of chemotherapy, and have CIPN symptoms. The study will be considered successful if at least 70% of participants complete 12 or more light therapy sessions. The current status of this study is unclear, and it plans to enroll 20 participants.

Study design
This is a single-arm pilot study, meaning all 20 participants will receive the light therapy. It is not specified if participants or researchers will be aware of the treatment being given.
What's involved
You would use the Anodyne Therapy System Model 120 at home for 15 minutes per day, 3 days per week, for 6 weeks. Your symptoms will be measured at the beginning and one week after the therapy ends.
Compensation
Not stated in the trial record.
Follow-up
Your neuropathy symptoms will be measured one week after the 6-week intervention is completed.

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NCT07019259

Light Therapy for Chemotherapy Induced Peripheral Neuropathy in Childhood Cancer Survivors

Recruiting
NAAges 5+Interventional
Yale University
~20 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:Anodyne Therapy System

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of light therapy protocol
Measured over 7 weeks
Cancer
Childhood Cancer
Chemotherapy-induced Peripheral Neuropathy
2 sites across 1 states
Connecticut2
  • Rozalyn Rodwin, MD · PRINCIPAL_INVESTIGATOR · Yale University

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Eligibility criteria

Inclusion

History of childhood cancer (\<21 years of age at diagnosis)
Current age five years or older (due to availability of validated measures for CIPN in this age group)
History of exposure to vinca alkaloid, platinum, or other chemotherapeutic agent that can cause CIPN
CIPN as assessed by a trained physical therapist defined as a score of four or higher on the ped-mTNS (for survivors \<18 years old at evaluation), or the mTNS (for survivors 18 years or older at evaluation)

Exclusion

Currently Pregnant or lactating (by patient report, at initiation or at any point of the study)
Inability to sit still for at least 15 minutes
Diagnosis of neuropathy prior to cancer treatment
Active cancer diagnosis or cancerous skin lesion
Central nervous system tumor (due to lack of validated measures for CIPN in this population)
Cancer lesion or open wound in the area to be treated, or any condition that can potentially be made worse by the correct or incorrect use of the device.
  • Feasibility of light therapy protocol7 weeks

    Measured as proportion of participants adhering to protocol (completing 12 of 18 sessions), with ≥70% of participants adhering to the protocol indicating feasibility