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Study on PEEP Titration and Body Positioning in Acute Respiratory Failure

This study is looking at how body weight and fat distribution affect how well two common treatments work for Acute Hypoxemic Respiratory Failure (AHRF). AHRF is when your lungs can't get enough oxygen. The treatments being studied are PEEP Titration Using Electrical Impedance Tomography (EIT) and Body Positioning (supine and prone). Researchers want to see if these treatments improve lung function differently in people with various body types. You might be able to join if you are 18 to 80 years old, have AHRF, and are on a breathing machine. The main goal is to measure lung pressure changes with these treatments. The study is currently unclear on its recruitment status and plans to enroll 80 participants.

Study design
This interventional study plans to enroll 80 participants. It is not specified if it is randomized or blinded.
What's involved
You will have EIT belts placed on your chest and a sensor in your breathing tube. You will be ventilated in both supine and prone positions for assessments.
Compensation
Not stated in the trial record.
Follow-up
No follow-up visits or post-discharge interventions are planned.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07019987

Adiposity Distribution in Acute Respiratory Failure

Not Yet Recruiting
NAAges 18–80InterventionalDiagnostic
Maurizio F. Cereda, MD
~80 participants
Updated 2025-06-13 on ClinicalTrials.gov
What's tested:PEEP Titration Using Electrical Impedance Tomography (EIT)Body Positioning: Supine and Prone

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Driving pressure with PEEP titration and prone position
Measured over Day 1, after 30 minutes in each combination of PEEP and body position

Conditions

Acute Hypoxemic Respiratory Failure
Obesity

Explore related trials

Acute hypoxemic respiratory failureObesity

Where it's being run

1 sites across 1 states
Massachusetts1

Who to contact

Maurizio F Cereda, MD
[email protected]
16176430987
Email the study team

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Eligibility criteria

Inclusion

AHRF with PaO2/FiO2 \<= 300 mmHg) intubated for less than 72 hours
Presence of an arterial line for blood gas measurement and blood pressure monitoring
18 years or older

Exclusion

Suspected pregnancy, pregnancy or less than six weeks postpartum
Younger than 18 years or older than 80 years.
Subject enrolled in another interventional research study
Presence of pneumothorax
Usage of any devices with electric current generation such as pacemaker or internal cardiac defibrillator
Preexisting chronic lung disease or pulmonary hypertension
Acute cardiac failure causing pulmonary edema
Past medical history of lung malignancy or pneumonectomy, or lung transplant
Hemodynamic instability, defined as:
Persistent systolic blood pressure \<90 mmHg and/or \>180 mmHg despite the use of vasopressor or vasodilators, or
Requiring an increment in inotropic-vasopressors over the past two hours just before enrollment: more than 15 mcg/min for norepinephrine and dopamine, more than 10 mcg/min in epinephrine; and more than 50 mcg/ min for phenylephrine.
Contraindications to placement in the prone position: complex abdominal surgical dressing, recent sternotomy, unstable spine or pelvic fractures, intracranial hypertension, serious facial injury
Extracorporeal life support

What this trial measures

  • Driving pressure with PEEP titration and prone positionDay 1, after 30 minutes in each combination of PEEP and body position

    The primary outcome will be the difference in driving pressure (inspiratory plateau pressure minus total PEEP, in cmH2O) in response to PEEP titration strategies and to prone position. Changes in driving pressure will be correlated with body mass index, and with measurements of thoracic, and abdominal circumference.