Stable Isotopes for Adults With Obesity Study
This study is looking at how the bodies of adults with obesity (BMI of 30 kg/m² or higher) use protein and sugar. Researchers want to understand whole-body protein efficiency using a method called Indispensable Amino Acid Oxidation (IAAO), and how the body handles sugar using a special glucose test. You would consume six hourly meals or a glucose drink, both containing special, safe tracers called stable isotopes. These tracers help researchers track how your body processes nutrients. The study aims to define how obesity affects these processes. This study is currently unclear on its recruitment status and plans to enroll 8 participants.
- Study design
- This is an interventional study with a crossover design, meaning participants will receive both types of interventions at different times. It plans to enroll 8 participants.
- What's involved
- You would participate in two study arms. In one, you'd consume six hourly drinks and have repeated blood, breath, urine, and muscle biopsies. In the other, you'd consume one glucose drink, and have periodic blood and breath tests over three hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- The protein efficiency will be measured over a 0-6 hour period, and glucose tolerance over a 0-3 hour period. These measurements will occur within one week of preliminary testing or the prospective arm.
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Stable Isotopes- Adults With Obesity
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Inclusion
What this trial measures
- Define obesity-related whole body protein efficiency based of the IAAO method0 - 6 hours observational period ingesting six hourly meals, within 1 week of preliminary testing. Baseline measures taken at --30 minutes.
Amino Acid Oxidation of phenylalanine will be measured using the IAAO method by periodic ingestion of amino acid mixture. Trials will start at \~7:00 am (-30 minutes) with a total duration of 6.5 hours (390 minutes) Measurements of breath (-30, 0, 120, 240, 270, 300, 330 and 360 minutes), Urine (-30, 0, 240, 300, and 360 minutes), muscle biopsy (-30 and 360 minutes) and blood (-30, 0, 30, 60, 90,120, 180, 240, 300, and 360 minutes) will be used to determine the whole body efficiency of protein in obese populations.
- Assessment of oral glucose tolerance based on a dual tracer technique0- 3 hour observational period. Within 1 week of the prospective arm. Baseline taken at -30 minutes.
Measure glucose kinetics via \[13C\] and D5 Glucose over 3 hours to determine glucose tolerance. Trials will start at \~7:00 am (-10 minutes) and last \~ 3 hours. (190 minutes)