This research study aims to understand how the lining of your nose, involved in your sense of smell, changes in healthy people and those with conditions like Alzheimer's disease or smell loss. The study will collect tissue from your nasal cavity using a simple brush technique (olfactory biopsy) to analyze the cells. You might also undergo smell testing using "scratch-and-sniff" tests and, for some, sniff specific odors like lavender or mint for about an hour. The main goal is to see how the genes in these olfactory cells change over five years. You may be eligible if you are between 18 and 80 years old and have early Alzheimer's (pre-clinical AD with positive biomarkers) or diagnosed Alzheimer's disease.

Study design

This is an interventional study planning to enroll 125 participants. It is a prospective study, meaning participants are followed forward in time.

What's involved

You would undergo smell testing and potentially an olfactory biopsy, which involves a simple brush technique in your nose. Some participants may also be asked to sniff an odor for about an hour.

Compensation

Not stated in the trial record.

Follow-up

The study is planned for completion over 5 years, during which changes in olfactory cells will be measured.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.