Neuroimaging of Parkinson's Disease
This observational study is looking at how Parkinson's Disease (PD) affects a newly discovered brain system called the Somato-Cognitive Action Network (SCAN). Researchers believe that problems with SCAN might be a key part of PD. They will use magnetic resonance imaging (MRI) scans to see if SCAN is connected to other brain areas important in PD and if these connections are different in people with PD. The goal is to identify SCAN as a specific area in the brain that is altered in PD patients, which could lead to new treatments. You may be able to join if you have a clinical diagnosis of Parkinson's Disease and do not have dementia, or if you are a healthy control with normal neurological exams and no family history of PD. The study aims to enroll 120 participants, but its current recruitment status is unclear.
- Study design
- This is an observational study, meaning no interventions are given. It plans to enroll 120 participants, including people with Parkinson's Disease and healthy controls.
- What's involved
- You would have 3-4 MRI sessions if you are a control participant, or 6-8 MRI sessions if you have Parkinson's Disease. These sessions will occur over 6 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 6 months, with measurements taken at that time.
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Neuroimaging of Parkinson's
At a glance
Conditions
NCT07024875
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
East Imaging Building
St Louis, Missourino site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Evan Gordon, PhD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
- Nico Dosenbach, MD/PhD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
- Scott Norris, MD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Cortico-subcortical connectivity to SCAN vs effectors6 months per participant; 3-4 sessions for controls, 6-8 sessions for PD patients
We will collect resting-state functional magnetic resonance imaging (fMRI) scans from the brains of all participants. From the fMRI scans, we will compute the functional connectivity between each of the subcortical brain structures relevant for Parkinson's disease (including substantia nigra, subthalamic nucleus, globus pallidus internus, and ventral intermediate nucleus of the thalamus) and each subdivision of primary motor cortex (Somato-Cognitive Action network and effector-specific regions controlling the hand, foot, and face). Functional connectivity will be computed as pairwise temporal correlations of the activity timecourses in each location. We hypothesize that subcortical structures will exhibit differential functional connectivity to the Somato-Cognitive Action network than to the effector-specific regions of primary motor cortex.