Study of Tolododekin Alfa and Cetrelimab for Advanced Non-Small Cell Lung Cancer

This study is looking at a new combination treatment for advanced non-small cell lung cancer (NSCLC). It combines tolododekin alfa, given as an injection directly into the tumor every three weeks, with cetrelimab, an anti-PD-1/PD-L1 antibody (a type of immunotherapy that helps your immune system fight cancer), also given every three weeks. The study aims to see how many participants respond to this treatment. You might be able to join if you are 18 or older, have advanced NSCLC, and meet other health criteria. Some participants will have already received other treatments, while others will be new to treatment for advanced NSCLC. The study plans to enroll about 60 people.

Study design
This is an interventional study planning to enroll 60 participants. It is testing a combination of two drugs.
What's involved
Participants will receive tolododekin alfa as an intratumoral injection every 3 weeks and cetrelimab every 3 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, Objective Response Rate, is measured at 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07027514

A Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Recruiting
PHASE1Ages 18+InterventionalTreatment
Ankyra Therapeutics, Inc
~60 participants
Updated 2025-11-18 on ClinicalTrials.gov
What's tested:tolododekin alfaCetrelimab

At a glance

Recruiting sites
5 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Objective Response Rate (ORR) by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1
Measured over 6 months
Non Small Cell Lung Cancer
5 sites across 4 states
New York2
Indiana1
Michigan1
North Carolina1

Opens a ready-to-send draft in your own email app — review before sending.

  • Objective Response Rate (ORR) by Response Evaluation Criteria In Solid Tumors (RECIST) v1.16 months

    Percentage of participants with complete response (CR) or partial response (PR) among all response evaluable participants