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Decellularized Human Placental Tissue for Rotator Cuff Repair

This study is looking at ways to improve healing after rotator cuff surgery. Rotator cuff tears are common, but sometimes the repair doesn't heal well. Researchers are comparing two approaches for full thickness rotator cuff tears: a standard repair, or a repair augmented with a decellularized human placental allograft patch. This patch is made from human placental tissue that has had its cells removed, leaving behind a natural scaffolding to help with healing. The main goal is to see if using this patch reduces the rate of the tear coming back (re-tear rate) one year after surgery. You may be able to join if you are 18 or older and have a full thickness rotator cuff tear. You cannot join if you have partial tears, certain subscapularis tears, or have had previous rotator cuff surgery.

Study design
This study plans to enroll 120 participants. It compares two different surgical approaches for rotator cuff repair.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year to measure the re-tear rate.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07027735

Decellularized Human Placental Extracellular Matrix Tissue for Rotator Cuff Repair Augmentation

Not Yet Recruiting
NAAges 18+InterventionalTreatment
Columbia University
~120 participants
Updated 2026-09-10 on ClinicalTrials.gov
What's tested:Rotator Cuff Repair with Allograft PatchRotator Cuff Repair with No Augmentation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Retear Rate
Measured over 1 year

Conditions

Rotator Cuff Tear

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NCT07027735

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • NewYorkPresbyterian Hospital @ Columbia University Irving Medical Center

    New York, New Yorkno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • William Levine, MD · PRINCIPAL_INVESTIGATOR · Columbia University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Age ≥ 18 years
Diagnosis of full thickness rotator cuff tear

Exclusion

Partial thickness tears
Full thickness subscapularis tears
Goutallier grades 3 and 4
Prior rotator cuff surgery

What this trial measures

  • Retear Rate1 year

    The primary outcome measure will be the postoperative retear rate, measured on one-year postoperative MRI