This study aims to understand if drinking alcohol changes the activity of a brain protein called Phosphodiesterase-4B (PDE4B). PDE4B may be involved in mental health conditions, and understanding its role could lead to new treatments for Alcohol Use Disorder (AUD). Researchers will give participants an intravenous (IV) infusion of ethanol (alcohol) and then inject a special tracer called 18F-PF-06445974. They will then use a PET scan to see how the tracer binds to PDE4B in the brain. The study is looking for 30 healthy individuals, aged 21 to 70, who drink socially but do not have AUD and are already part of another study (protocol 14-AA-0181). The main goal is to measure how much the tracer binds to PDE4B in the brain after alcohol, with results expected at 36 months.

Study design

This interventional study plans to enroll 30 participants. It uses a within-subject design, meaning each participant will be scanned both at baseline and after receiving alcohol.

What's involved

Participants will undergo two PET scans: one at baseline and another after receiving intravenous ethanol. They will also need to complete MRI tests and be in good general health.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, measuring distribution volume, will be assessed at 36 months after the study procedures.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.