Understanding Exosome Release in Obesity After a Meal

This study aims to understand how your body, specifically the fat tissue in your upper body, releases tiny particles called exosomes after you eat a meal. Researchers want to see if there are differences in this process between people with obesity and those with normal weight. You would consume a mixed meal drink (Ensure) and then have blood drawn over four hours. The main goal is to measure blood flow in your fat tissue after this meal. This study is for adults aged 18 to 55, including premenopausal women, who do not have diabetes or heart disease, and are not taking certain medications that affect blood flow or fat metabolism. The study plans to enroll 20 participants, but its current status is unclear.

Study design
This is an interventional study planning to enroll 20 participants to understand the body's response to a meal.
What's involved
You would consume a mixed meal drink and then have a series of blood draws over four hours.
Compensation
Not stated in the trial record.
Follow-up
Blood flow in fat tissue will be measured at 4 hours after the meal.

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NCT07031297

Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

Recruiting
NAAges 18–55InterventionalBasic science
Mayo Clinic
~20 participants
Updated 2026-08-05 on ClinicalTrials.gov
What's tested:Meal Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Adipose tissue blood flow
Measured over 4 hours
Obesity
1 sites across 1 states
Minnesota1
  • Kelli A. Lytle, Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Exclusion

Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
Diabetes, history of cardiovascular disease
Allergy to lidocaine
Post-menopausal women
Pregnant
  • Adipose tissue blood flow4 hours

    Blood flow will be measured in the upper body subcutaneous adipose tissue using Xenon washout and reported as blood flow in ml/min/100g adipose tissue.