A Polypill for Acute Coronary Syndrome

This study is looking at whether combining standard medications into one "polypill" can help people who have recently had acute coronary syndrome (ACS), which includes heart attacks. The polypill will contain aspirin, a P2Y12 inhibitor (like prasugrel or clopidogrel), and a high-intensity statin. Researchers want to see if taking these medicines together in one pill improves health outcomes over 6 months compared to taking them separately. You might be able to join if you are at least 18 years old, were hospitalized for ACS, had a procedure called percutaneous coronary intervention, and are currently taking aspirin, prasugrel or clopidogrel, and a high-intensity statin. The study is aiming to include 1000 participants.

Study design
This is a multi-center, randomized study, meaning participants will be randomly assigned to receive either the polypill or standard separate medications. The study plans to enroll 1000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main results will be measured at 6 months after starting the treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07032389

A Polypill for Acute Coronary Syndrome

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Texas Southwestern Medical Center
~1,000 participants
Updated 2026-07-10 on ClinicalTrials.gov
What's tested:Polypill

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Win ratio
Measured over 6-months
Acute Coronary Syndrome

NCT07032389

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Baylor Scott and White Health System

    Dallas, Texasstudy coordinator listed

    Recruiting

  • University of Texas Southwestern Medical Center

    Dallas, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

Age ≥ 18
Hospitalization for acute coronary syndrome with percutaneous coronary intervention
Discharged on aspirin, prasugrel or clopidogrel, and a high-intensity statin

Exclusion

Current need for systemic anticoagulation
Contraindication to receive any components of the polypill
History of allergic reaction or intolerance to aspirin, prasugrel or clopidogrel, or rosuvastatin
Comorbidities that might be expected to limit lifespan within the 12-month study period
Increased risk of bleeding or planned urgent surgery that would necessitate use of DAPT for \< 12 months
Inability to provide written informed consent
Pregnancy
  • Win ratio6-months

    The win ratio will include all-cause death, in-stent thrombosis, ischemic events (MI, hospitalization for unstable angina, unplanned revascularization), and bleeding events (hospitalization or ED visit for bleeding, red blood cell transfusion, or a bleeding event that leads to cessation of DAPT)