Varenicline for E-cigarette Cessation

This study is testing if a medication called varenicline (Chantix) can help people stop using e-cigarettes. You might be able to join if you are an adult, use e-cigarettes daily, and live in Connecticut or South Carolina. You cannot join if you use other tobacco products, have certain medical conditions, or are already getting treatment to quit tobacco. Participants will either receive varenicline or a placebo (an inactive pill that looks like the study drug) for 12 weeks, along with counseling. The main goal is to see how many people successfully quit e-cigarettes by week 12. The current status of this study is unclear.

Study design
This is a randomized, placebo-controlled study, meaning participants are randomly assigned to receive either varenicline or a placebo. The study plans to enroll 326 participants.
What's involved
You would take varenicline or placebo for 12 weeks. You will also have research assessments every 3 weeks during treatment.
Compensation
Not stated in the trial record.
Follow-up
There will be a final follow-up visit at week 26, which is 14 weeks after the treatment period ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07040566

A Trial of Varenicline for E-cigarette Cessation

Recruiting
PHASE2Ages 18+InterventionalTreatment
Yale University
~326 participants
Updated 2025-12-17 on ClinicalTrials.gov
What's tested:Varenicline 1mg BIDPlacebo

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Participants Abstinent From E-cigarette Use at Week 12
Measured over Week 12
E-cigarette Use
Vaping
Nicotine Dependence
2 sites across 2 states
Connecticut1
South Carolina1
  • Lisa Fucito, PhD · PRINCIPAL_INVESTIGATOR · Yale University
  • Benjamin Toll, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

report daily use of an e-cigarette containing nicotine
live in Connecticut or South Carolina

Exclusion

regular use of other tobacco products besides e-cigarettes
medical contraindications for varenicline use
current treatment for tobacco cessation
lack proficiency in English
  • Number of Participants Abstinent From E-cigarette Use at Week 12Week 12

    7-day point-prevalence e-cigarette abstinence (PPA) at Week 12 defined as no ecigarette use \[and no use of any combusted tobacco product\], not even a puff, biochemically verified by saliva cotinine