Mindfulness to Enhance Cognitive Health in Latino Older Adults

This study is looking at whether a special mindfulness program, called MBSR (Mindfulness-Based Stress Reduction), can help improve brain health in Latino older adults. Researchers want to see if this program can lower the risk of Alzheimer's disease. You might be able to join if you are 65 or older, identify as Hispanic/Latino, live in the community, are medically stable, and haven't had a lot of mindfulness training before. The study will measure brain activity using EEG (electroencephalogram) and look at how well participants perform on certain thinking tasks. The study is currently unclear about its recruitment status and plans to enroll 60 participants.

Study design
This study will involve 60 Latino older adults who will be randomly assigned to either receive 8 weeks of mindfulness training or be in a wait-list control group.
What's involved
If you join, you will complete a baseline assessment, then either participate in 8 weeks of mindfulness training or be in a wait-list group. During the 8 weeks, you will also answer questions on your phone 4 times a day on 3 random days per week.
Compensation
Not stated in the trial record.
Follow-up
Your brain activity and performance on thinking tasks will be measured at the beginning of the study and immediately after the 8-week intervention period.

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NCT07040904

Mindfulness to Enhance Cognitive Health in Latino Older Adults

Recruiting
NAAges 65+InterventionalBasic science
Washington University School of Medicine
~60 participants
Updated 2026-05-11 on ClinicalTrials.gov
What's tested:mindfulness

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
EEG brain markers of cognitive functioning
Measured over Time-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention
+8 more outcomes measured
Mindfulness
Alzheimer's Disease Related Dementia
1 sites across 1 states
Missouri1

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Eligibility criteria

Inclusion

Hispanic/Latino
Age 65 and older
Male, female, or non-binary
Community living
Medically stable and willing to undergo the study procedures
No extensive mindfulness training experience

Exclusion

Clinically unstable psychiatric disorder that requires immediate treatment (e.g., ECT)
Medical conditions suggesting significantly shortened lifespan (e.g., metastatic cancer) or prohibiting safe participation in the interventions/assessments (e.g., Parkinson's disease, musculoskeletal conditions)
Sensory impairment (hearing, vision) preventing participation
Current alcohol or substance abuse
Current/concurrent cognitive training known to affect neuroplasticity (e.g., brain-training programs), or other interventions expected to affect neuroplasticity significantly (e.g., psychedelics, cholinesterase inhibitors, high-dose sedatives).
  • EEG brain markers of cognitive functioningTime-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention

    EEG indices of cognitive performances evoked by task stimuli and participant responses. ERP components of attention and cognitive control during task performance, focused on target-related P3 amplitude.

  • EEG brain markers of cognitive functioningTime-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention

    EEG indices of cognitive performances evoked by task stimuli and participant responses. ERP components of attention and cognitive control during task performance, focused on cue-related Contingent Negative Variation (CNV).

  • AXCPT behavioral performance (reaction time)Assessed at 2 timepoints: baseline/pre-intervention immediately post-intervention

    Behavioral performance indices during AXCPT task: AX-CPT - reaction time in milliseconds

  • AXCPT behavioral performance score (accuracy)Assessed at 2 timepoints: baseline/pre-intervention immediately post-intervention

    Behavioral performance indices during AXCPT task: AX-CPT - % accuracy AX-CPT --% accuracy

  • Five Facet Mindfulness Questionnaire (FFMQ) scorePerformed during the intervention (3x /week for 8 weeks)

    Five Facet Mindfulness Questionnaire (FFMQ) is a 39-item self-report inventory used to measure five distinct facets of mindfulness. The five facets are observing, describing, acting with awareness, non-judging of inner experience, and non-reactivity to inner experience, each rated on a 5-point Likert scale.

  • The Mindful Attention Awareness Scale (MAAS) scorePerformed during the intervention (3x /week for 8 weeks)

    The Mindful Attention Awareness Scale (MAAS) is a 15-item measure of mindfulness that prioritizes assessment of the general tendency to be attentive and aware of experiences in the present moment. It is is rated on a 6-point Likert scale (almost always, very frequently, somewhat frequently, somewhat infrequently, very infrequently, almost never).

  • Cognitive and Affective Mindfulness Scale (CAMS-R) scorePerformed during the intervention (3x /week for 8 weeks)

    Cognitive and Affective Mindfulness Scale (CAMS-R) is used to evaluate symptoms of mindfulness as EMA (ecological momentary assessment) questions. It will be measured in a Likert scale (Not at all, Somewhat, Quite a bit, Almost completely)

  • Patient-Reported Outcomes Measurement Information System (Promis) scorePerformed during the intervention (3x /week for 8 weeks)

    PROMIS (Patient-Reported Outcomes Measurement Information System) are item banks that measure common health outcomes across the domains of physical, mental, and social health.

  • National Institutes of Health Toolbox Emotion Battery (NIH-TOOLBOX-EB) scorebaseline (pre-intervention) & immediately post-intervention

    National Institutes of Health Toolbox Emotion Battery for English- and Spanish-speaking adults (NIH-TOOLBOX-EB): National Institutes of Health Toolbox Emotion Battery for English- and Spanish-speaking adults (NIH-TOOLBOX-EB) A series of scales that will be rated on a 5-point Likert scale which include: 1. General Life Satisfaction 2. Meaning and Purpose 3. Loneliness 4. Sadness 5. Positive Affect 6. Fear Affect 7. Perceived Stress 8. Resilience Scale 9. Sleep Quality Scale