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MINT Conditioning to Improve Gait After Stroke

This study is testing two training methods to improve walking for people who have had a stroke. One method is called myoelectric interface for neurorehabilitation (MINT) conditioning, which aims to reduce abnormal muscle co-activation (when muscles work against each other). The other method is training to control activity in just one muscle. You might be able to join if you are 18-85 years old, had a stroke at least six months ago that affects your leg, have moderate to severe difficulty walking, can stand on your own, and show abnormal muscle co-activation. The study will measure how far you can walk in 10 meters at the start and after four weeks to see if the training helps. The study plans to enroll 72 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 72 participants. It is testing two different training methods.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your walking ability will be measured at the start of the study and again after 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07041775

MINT Conditioning to Improve Gait

Recruiting
NAAges 18–85InterventionalTreatment
Northwestern University
~72 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:myoelectric interface for neurorehabilitation (MINT) conditioningOne muscle myoelectric feedback

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
10-m walk test
Measured over Baseline and 4 weeks

Conditions

Stroke
Stroke Gait Rehabilitation

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Stroke

NCT07041775

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Northwestern University

    Chicago, Illinoisstudy coordinator listed

    Recruiting

  • University of Texas Southwestern Medical Center

    Dallas, Texasstudy coordinator listed

    Not yet recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Marc Slutzky, MD, PhD · PRINCIPAL_INVESTIGATOR · Northwestern University

Who to contact

Marc Slutzky, MD, PhD
[email protected]
312-503-4653
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Age at enrollment is 18 to 85
Leg impairment from unilateral stroke at least 6 months prior to screening
Severe to moderate gait impairment (ambulatory with a maximum walking speed of 0.8 m/s, i.e., half of normal speed)
Able to stand without assistance
Clinically observable gait asymmetry
Abnormal co-activation between adductor magnus and rectus femoris (R greater than or equal to 0.5)

Exclusion

Cognitive impairment with at least moderately impaired attention on digit-span test, or unable to follow instructions of the MINT task
Visual impairment (such as hemianopia) preventing sufficient perception of the screen to play the games
Anesthesia or severe neglect in the affected leg, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest) that impairs ability to play the games
Participation in another study on the affected leg, or any pharmacological study, within 6 weeks of enrollment
Inability to understand or follow commands in English due to aphasia or other reason that makes it impossible to perform the training
Diffuse or multifocal infarcts
Substantial leg or other pain preventing participation for 60 minutes a day
Spasticity treatment (pharmacological or Botox) on the affected leg within past 3 months
Severe osteoporosis causing hip or other fractures
History of multiple falls within the last year, use of walker for balance, or falling during stance while in the lab in the first session.
Contracture limiting the range of motion of the leg
Current pregnancy
From the TMS portion of the study only: History of epilepsy in adulthood requiring antiseizure medications; recent/current alcoholism or benzodiazepine/barbiturate abuse or recent history of alcohol/benzodiazepine/barbiturate withdrawal, recent history of cocaine or amphetamine use, skull fractures or skull deficits, concussion within the last 6 months, unexplained recurring headaches, vagus nerve stimulator, cochlear implant, deep brain stimulator, intracranial/carotid stents, cardiac pacemaker/AICD.

What this trial measures

  • 10-m walk testBaseline and 4 weeks

    The 10-m walk test measures gait speed