This study is looking at whether adding histotripsy to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver (colorectal liver metastasis). Histotripsy uses sound waves to mechanically break down tumors without surgery or heat. You might be able to join if you have colorectal cancer that has spread to your liver, or to your liver and a small amount to your lungs. You should also be receiving certain chemotherapy treatments (5-FU with oxaliplatin or irinotecan), or have recently started or finished them. The study wants to see if this combination improves how long you live without your cancer getting worse. The study is currently unclear on its recruitment status and plans to enroll up to 100 participants.

Study design

This is a study testing the benefits of histotripsy plus chemotherapy. Up to 100 participants with colorectal cancer liver metastasis will be included.

What's involved

You will receive standard chemotherapy and histotripsy treatment. You will also have occasional CT scans, biopsies of liver lesions, and blood draws at in-person visits.

Compensation

Not stated in the trial record.

Follow-up

The study measures tumor viability at 90 days after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.