Social Functioning in Opioid Use Disorder Study

This study is looking at how social functioning affects treatment for Opioid Use Disorder (OUD). It's testing an internet-based cognitive behavioral therapy program called CBT4CBT-Buprenorphine for people who are already taking buprenorphine. Researchers want to understand how social behaviors, social reward, and social connection are linked to successful OUD treatment. They will also gather information from a concerned significant other (CSO) in addition to the patient. You may be able to join if you are 18 or older, have OUD, and have been on buprenorphine for no more than 4 weeks. The study aims to enroll 230 participants, but its current status is unclear.

Study design: This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 230 participants.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: Social behaviors, social reward, and social connection will be measured from Week 1 to Week 14.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Social Functioning in Opioid Use Disorder

Recruiting

NAAges 18+InterventionalTreatment

Medical University of South Carolina

~230 participants

Updated 2026-08-17 on ClinicalTrials.gov

What's tested:CBT4CBT-Buprenorphine

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Affiliative social behaviors

Measured over Week 1 to Week 14

+4 more outcomes measured

Conditions

Opioid Use Disorder

Where it's being run

1 sites across 1 states

South Carolina1

Study leadership

Amber M Jarnecke, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina
Rachel Tomko, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Amber Anderson, BA

[email protected]

843-876-3115

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Any sex or gender; any race or ethnicity; aged 18 years or older

Patient participants must meet DSM-5 diagnostic criteria for current (i.e., past 12 months) OUD (assessed via the Quick Structured Clinical Interview for DSM-5; Quick SCID)

Patient participants must be on medication for opioid use disorder (MOUD), as prescribed by their provider, for no more than 12 weeks prior to study initiation

Patient participants must be in treatment at a clinic in South Carolina

Concurrent substance use disorders (e.g., alcohol, cannabis) for the patient participant are acceptable, provided opioids are the patient participant's primary substance of choice

Patient participants must identify a CSO participant who consents to participation in the study as well

Exclusion

Moderate-to-severe opioid withdrawal as defined by a score of ≥21 on the Subjective Opioid Withdrawal Scale

Meeting DSM-5 criteria for a history of or current psychotic or bipolar disorders

Current suicidal or homicidal ideation and intent; participants who present a serious suicide risk are likely to require hospitalization during the study and they will be referred clinically

CSO participants meeting DSM-5 criteria for opioid use disorder or any other substance use disorder, excepting tobacco use disorder, mild cannabis use disorder, and mild alcohol use disorder

Severe interpersonal violence in the past six months between the patient and the CSO, as defined by an adapted version of the Conflict Tactics Scaled Revised (CTS-2)

Pregnancy for patient participants

Prisoners, institutional individuals, and children will not be recruited for this study.

What this trial measures

Affiliative social behaviorsWeek 1 to Week 14
Checklist of 12 items assessing social interaction behaviors (adapted from the Social Behavior Inventory; Moskowitz, 1994), summed, averaged, and ipsatized to assess dominant behavior, submissive behavior, agreeable behavior, and quarrelsome behavior. Higher scores reflect greater frequency of the type of behavior.
Social rewardWeek 1 to week 14
1 item assessing how much an individual liked their social interactions (adapted from Geyer, et al., 2018). Higher scores reflect more enjoyment from social interactions.
Social connectionWeek 1 to week 14
1 item assessing how close an individual felt with others (adapted from Flores et al., 2015). Higher scores reflect greater feelings of closeness.
Medication for opioid use disorder adherenceWeek 1 to week 14
2 items assessing daily adherence to taking medication for opioid use disorder (response options: yes; no, I took it, but not as prescribed; no, I did not take buprenorphine) and at what dose (in mgs).
CravingWeek 1 to week 14
1 item assessing craving for opioids (adapted from Mun et al., 2021; Ellis et al., 2022). Higher scores reflect greater craving.

Trialytics