Molecular and Cellular Profiling of Uterine Lavage During Gynecologic Surgery

This study is looking at a new way to collect cells and fluid from the uterus during gynecologic surgery. It uses a procedure called uterine lavage, where saline (saltwater) is gently introduced into your uterus and then collected. Researchers want to see if this method is practical and safe, and to understand what kinds of cells are present in these samples. You might be able to join if you are 18 or older, having gynecologic surgery at Stanford Healthcare, and have an intact uterus, cervix, and at least one intact fallopian tube and ovary. The study aims to enroll 50 participants, and its current status is unclear.

Study design
This is an interventional study designed to test the feasibility of a new collection method. It will enroll 50 participants consecutively, and all will receive the uterine lavage procedure.
What's involved
If you participate, you will undergo the uterine lavage procedure during your gynecologic surgery. The study's primary goal is to characterize the cellular composition of the fluid collected at that time.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, characterizing cellular composition, is measured at the time of gynecologic surgery. No further follow-up is specified.

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NCT07044505

Molecular and Cellular Profiling of Uterine Lavage Collected During Gynecologic Surgery

Recruiting
NAAges 18+InterventionalBasic science
Stanford University
~50 participants
Updated 2025-11-05 on ClinicalTrials.gov
What's tested:Uterine Lavage

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Characterization of cellular composition in uterine lavage fluid
Measured over At time of gynecologic surgery
Gynecologic Cancer
Gynecologic Disease
Gynecological Surgery
Uterine Cancer
1 sites across 1 states
California1
  • James Ford, MD · PRINCIPAL_INVESTIGATOR · Stanford University

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Eligibility criteria

Inclusion

Undergoing gynecologic surgery with Stanford Healthcare
Intact uterus and cervix
At least one intact fallopian tube and ovary (on the same side)
Aged 18 years or older
Ability to understand and the willingness to provide written informed consent.

Exclusion

Known endometrial or cervical cancer or endometrial or cervical intraepithelial neoplasia
Status post bilateral salpingectomy or tubal ligation
Lack of consenting capacity
Positive preoperative pregnancy test
Active uterine bleeding (i.e. menses, etc.)
Intrauterine device in place
Non-English speaking (requires interpretor)
  • Characterization of cellular composition in uterine lavage fluidAt time of gynecologic surgery

    Quantification and classification of cell types obtained from uterine lavage specimens using cytology and/or flow cytometry.