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Monitoring Repetitive Head Impact with Gamma-glutamylcysteine Supplementation

This study is looking at whether an oral supplement called Gamma-glutamylcysteine (GGC) can help people who have experienced many head impacts. The goal is to see if GGC can increase a natural antioxidant in the brain called glutathione (GSH), which might reduce damage from repetitive head impacts. Researchers will measure changes in glutathione levels in the brain and blood, as well as blood iron levels, after taking GGC. They will also look at how GGC affects thinking and memory. You might be able to join if you are a retired NFL player or military personnel with combat experience, are between 30 and 70 years old, and have memory or behavior concerns. The study is currently unclear about its recruitment status.

Study design
This study is an interventional trial planning to enroll 30 participants. It is designed to evaluate the effects of GGC supplementation.
What's involved
Participants will take 400mg of Gamma-glutamylcysteine (GGC) orally twice per day. Changes in brain and blood levels will be measured at 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months to measure changes in brain glutathione, blood glutathione, and blood iron levels.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07050173

Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation

Recruiting
PHASE1Ages 30–70InterventionalPrevention
Pravat Mandal
~30 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Gamma-glutamylcysteine (GGC)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in brain glutathione levels (mM) in people with Repetitive Head Injury (RHI) using Magnetic Resonance Spectroscopy in pre and post supplementation.
Measured over 12 months
+2 more outcomes measured

Conditions

Repetitive Head Impacts

Explore related trials

Brain InjuryRepetitive Head Impact

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Pravat K Mandal, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Pravat K MANDAL, PHD
[email protected]
4126999561
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Retired NFL player, retired Navy SEAL/army personnel with combat experience exposed to repetitive head impact;
Memory and behavioral complaint per self- or informant-report;
Age (30 to 70 years of age) years;
Able to read and write in English and to give consent to participate in the study.

Exclusion

Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments in the eyes, skin, or body.
Subjects with claustrophobia.
Subject with mild cognitive impairment \[TICS score of 29 or lower OR \>=1.0 standard deviations below age-expectation on at least two cognitive members within the same cognitive domain (e.g. memory, attention, etc.) on the baseline neuropsychological testing;
Subjects with a history of cancer;
Subjects with active psychosis or delirium;
Subjects with chronic kidney (creatinine \> 1.5mg/dL) or liver disease (AST ≥ 1.5 ULN; ALT ≥1.5 ULN) within 30 days prior to enrollment;
Subjects on antioxidant therapy (gingko biloba or N-acetylcysteine) or illicit drug abuse/dependence (cocaine, heroin, marijuana, or fentanyl;
Repeated head injury patients with neurosurgical intervention and;
Subjects with repeated head injury within the last 90 days.

What this trial measures

  • Changes in brain glutathione levels (mM) in people with Repetitive Head Injury (RHI) using Magnetic Resonance Spectroscopy in pre and post supplementation.12 months

    (MRS) is a non-invasive imaging technique, to detect various neurochemical (e.g. glutathione) using MEGA-PRESS sequence from 1H MR spectroscopy.

  • Changes in baseline blood glutathione levels (µmol/l) in people with RHI due to GGC supplementation.12 months
  • Changes in blood iron levels(ng/μl) in people with RHI due to GGC supplementation.12 months