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Observational Study on Kidney Disease in Heart Failure with Preserved Ejection Fraction (HFpEF) and Obesity

This observational study aims to understand how kidneys handle protein and salt in people with Heart Failure with Preserved Ejection Fraction (HFpEF) and obesity, compared to healthy individuals. HFpEF means your heart doesn't fill with enough blood when it rests, leading to less blood pumped out. Researchers will observe how your body responds to a high protein and sodium meal. You may be eligible if you are an adult between 18 and 75 years old, have normal kidney function, no heart failure, and a BMI between 25-30 kg/m2. The study is looking for 60 participants and its current status is unclear.

Study design
This is an observational study planning to enroll 60 participants. It compares individuals with HFpEF and obesity to healthy participants.
What's involved
Participants will consume a high protein and sodium meal. Researchers will measure changes in your kidney function and urine sodium excretion at 5 hours.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken at 5 hours after the meal.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07052539

The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

Recruiting
Not specifiedAges 18–75Observational
University of Mississippi Medical Center
~60 participants
Updated 2025-07-04 on ClinicalTrials.gov
What's tested:High protein and sodium meal

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in measured GFR
Measured over 5 hours
+1 more outcome measured

Conditions

Chronic Kidney Disease
Heart Failure With Preserved Ejection Fraction (HFPEF)
Obesity (Disorder)

Explore related trials

Chronic Kidney DiseaseHeart failure with normal ejection fractionObesity

Where it's being run

1 sites across 1 states
Mississippi1

Study leadership

  • Marissa C Tio, MD · PRINCIPAL_INVESTIGATOR · University of Mississippi Medical Center

Who to contact

Tekka Johnson
[email protected]
601-496-7834
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults 18-75 years old
Normal kidney function
No heart failure
BMI 25-30kg/m2
Adults 18-75 years old
eGFR \>= 60 mL/min/1.73m2
BMI \> 35 kg/m2
Adults 18-75 years old
eGFR \>= 60 mL/min/1.73m2
BMI \> 35 kg/m2
Diagnosis of HFpEF (chart diagnosis, LVEF \> 55% on echo, H2FPEF score 6-9 or HFA-PEFF score 5 or 6

Exclusion

Diagnosis of chronic illness
eGFR\<60mL/min/1.73m2
Pregnancy or breast feeding
History of cutaneous or allergic reaction to iodine-based products of contrast dyes
Hemoglobin levels \<7mg/dL
Acute illness or hospitalization event within 3 months
Unable to stop NSAIDs
Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
Current use of nicotine or recreational drugs, chronic drinker
Diagnosis of Heart Failure
Diagnosis of chronic illness
eGFR\<60mL/min/1.73m2
Pregnancy or breast feeding
History of cutaneous or allergic reaction to iodine-based products of contrast dyes
Hemoglobin levels \<7mg/dL
Acute illness or hospitalization event within 3 months
Unable to stop NSAIDs
Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
Current use of nicotine or recreational drugs, chronic drinker
NYHA class III/IV
Urinary retention screen +
Mobility issues
History of RRT or kidney transplant
Acute illness/hospitalization in the past 3 months
History of cancer, chemo, or XRT
Pregnant/breastfeeding
History of allergies to contrast
Hemoglobin \< 7
Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
Unable to stop NSAIDs
Current use of nicotine or recreational drugs, chronic drinker

What this trial measures

  • Change in measured GFR5 hours
  • Change in urine sodium excretion5 hours