Enamel Matrix Derivatives for Gum Tissue Thickness Around Dental Implants

This study is looking at whether a product called Enamel Matrix Derivative (EMD) can help make gum tissue thicker around dental implants. EMD is an FDA-approved medical device that has been used in gum procedures since 1996 to help with healing and tissue growth. Researchers want to see if applying EMD during the second stage of implant uncovering (when the implant is exposed) will lead to thicker gum tissue around the implant. They will measure gum thickness and the width of the attached gum tissue at one and three months after the procedure. You may be able to join if you are 18 to 89 years old, need your implant uncovered, and can attend all study visits. The study plans to enroll 32 participants.

Study design
This interventional study plans to enroll 32 participants. It will compare the use of Enamel Matrix Derivative (EMD) to not using EMD during implant uncovering.
What's involved
You would have EMD applied during your implant uncovering procedure, followed by an intraoral scan. You will also have follow-up intraoral scans at one and three months after the procedure.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for three months after the procedure to measure gum tissue changes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07053969

The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness

Recruiting
NAAges 18–18InterventionalTreatment
The University of Texas Health Science Center at San Antonio
~32 participants
Updated 2025-11-12 on ClinicalTrials.gov
What's tested:Enamel Matrix Derivative

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mucosal Thickness
Measured over One month and 3 months
+1 more outcome measured
Dental Implantation
Missing Teeth
Periodontitis, Adult
Mucositis
1 sites across 1 states
Texas1
  • Angela Palaiologou-Gallis, DDS · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center at San Antonio

Opens a ready-to-send draft in your own email app — review before sending.

  • Mucosal ThicknessOne month and 3 months

    Mucosal thickness at 1 and 5mm below the free gingival margin will be measured

  • Change in Keratinized mucosal widthOne month and 3 months

    measurement of keratinized mucosal width at one and three months after surgical uncovering of the dental implant