Lidocaine and Methylprednisolone for Headaches After Brain Bleed
This study is looking into a new way to treat severe headaches that can happen after a subarachnoid hemorrhage (SAH), which is a type of bleeding around the brain. These headaches can be very painful and last a long time. The study will test if injecting two medications, Lidocaine hydrochloride and Methylprednisolone sodium succinate, directly into a specific artery in the head (the middle meningeal artery or MMA) can help reduce headache severity. You might be able to join if you are an adult (18 or older) with a confirmed SAH and are already having a procedure called DSA (digital subtraction angiography). The study will measure how much your headache pain changes over 12 weeks. The current status of this study is unclear, and it plans to enroll 25 participants.
- Study design
- This is a single-center study where all participants receive the treatment. It is an open-label study, meaning both you and the study team will know what treatment you are receiving. The study aims to enroll 25 participants.
- What's involved
- You would receive injections of Lidocaine hydrochloride and Methylprednisolone sodium succinate during a DSA procedure. Your headache severity will be measured at different times, including at discharge and at follow-up visits up to 12 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for headache severity from baseline up to 12 weeks after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Daniel M S Raper, MBBS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
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What this trial measures
- Headache SeverityFrom baseline to 12-week follow-up
Headache Impact Test-6 (HIT-6) score from baseline (pre-intervention) to 12 weeks postoperatively. Scores range from 36 (no impact) to 78 (severe impact), with higher scores indicating a greater negative impact.