Mirikizumab for Crohn's Disease and Ulcerative Colitis in Older Adults

This study is looking at how well and how safely Mirikizumab works for adults aged 60 and older who have moderate to severe Crohn's disease (CD) or ulcerative colitis (UC). These are types of inflammatory bowel disease (IBD) that cause swelling and irritation in your digestive system. Mirikizumab is already approved for IBD, but there's not much information about its use in older adults, who often have other health concerns. This study aims to see if Mirikizumab can help older patients manage their condition safely. Success will be measured by whether participants achieve clinical remission (a significant reduction in symptoms) at 24 weeks.

Study design
This is an interventional study planning to enroll about 150 participants. It will test Mirikizumab according to FDA-approved dosing guidelines, without a comparison group.
What's involved
Participants will receive scheduled doses of Mirikizumab at predefined intervals throughout the study period. Clinical remission will be measured at 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for measuring clinical remission is at 24 weeks.

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NCT07059130

Evaluating the Efficacy and Safety of Mirikizumab in Adults Over 60 With Moderate to Severe Crohn's Disease and Ulcerative Colitis

Not Yet Recruiting
PHASE4Ages 60–99InterventionalTreatment
Rubix LS
~150 participants
Updated 2025-07-10 on ClinicalTrials.gov
What's tested:Mirikizumab

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical Remission at Week 24
Measured over 24 weeks
Crohn Disease (CD)
Crohns Disease
Ulcerative Colitis (UC)
1 sites across 1 states
Massachusetts1

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  • Clinical Remission at Week 2424 weeks

    Clinical remission is defined as achieving either: Crohn's Disease Activity Index (CDAI) score less than 150 (for participants with Crohn's Disease), or Mayo Score of 2 or less (for participants with Ulcerative Colitis).