Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

{ "Cognitive Processing Therapy (CPT) for Perinatal PTSD", "This study is looking at two ways to deliver Cognitive Processing Therapy (CPT) for pregnant women who have Posttraumatic Stress Disorder (PTSD). You would receive either standard CPT (one 60-minute session per week for 12 weeks) or 'Massed CPT' (two 60-minute sessions each day for 5 days). The study wants to see which approach works better to reduce PTSD and depression symptoms, and how it affects the bond between mother and baby. Researchers will also gather information about pregnancy and newborn health. To join, you must be a woman between 18 and 46 years old, pregnant (less than 25 weeks), and have a confirmed PTSD diagnosis. Your current medications must be stable.", "design": "This study plans to enroll 60 participants. You would be randomly assigned to receive either standard CPT or Massed CPT.", "commitments": "You would participate in either 12 weekly sessions or 10 sessions over 5 days. Your PTSD symptoms will be checked at the start, and then at 1, 4, 8, 12, and 16 weeks after treatment begins.", "compensation": "Not stated in the trial record.", "follow_up": "Your PTSD symptoms will be monitored for 16 weeks after you start treatment.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07060144

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

Recruiting
NAAges 18–46InterventionalTreatment
University of Texas at Austin
~60 participants
Updated 2026-06-16 on ClinicalTrials.gov
What's tested:Regular CPTMassed CPT

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)
Measured over Baseline, then at 1 week, 4 weeks, 8 weeks, 12 weeks, and 16 weeks following initiation of treatment in both the mCPT and traditional CPT groups
Posttraumatic Stress Disorder (PTSD)
Pregnancy
1 sites across 1 states
Texas1
  • Erin Richardson · PRINCIPAL_INVESTIGATOR · University of Texas at Austin

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Eligibility criteria

Inclusion

Female, ages 18-46, Pregnant (\< 25 weeks), able to read and write in English, History of at least 1 criterion A trauma, Primary diagnosis of PTSD (confirmed by SCID), Psychotropic medications must be stable with no changes ≥ 2 weeks (≥ 6 weeks for fluoxetine), and no medication changes can be made during the course of therapy

Exclusion

Not currently pregnant, Diagnosis of bipolar disorder, psychotic disorders, Suicidal ideation with plan or intent, Substance use disorder, Regular benzodiazepine use (\> 4x weekly)
  • Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)Baseline, then at 1 week, 4 weeks, 8 weeks, 12 weeks, and 16 weeks following initiation of treatment in both the mCPT and traditional CPT groups

    PTSD Checklist for DSM-5 (PCL-5) will be used to collect information on PTSD symptoms. The PCL-5 for DSM-5 is a 20-item self-report measure. Higher scores reflect greater PTSD severity. Scoring is based on how much the patient has been bothered by the symptoms on a scale from "0 = not at all" to "4 = extremely." PCL-5 total symptom severity scores range from 0 to 80 with higher scores indicating greater PTSD severity. PCL-5 Monthly will be collected at Visit 1, and the PCL-5 weekly will be collected at 1 week, 4 weeks, 8 weeks, 12 weeks, and 16 weeks following initiation of treatment in both groups.