Lidocaine Infusion for Chronic Debilitating Migraines

This study is looking at how well a treatment called bilateral middle meningeal artery lidocaine infusion works for people with chronic, very severe migraines. This treatment involves carefully putting lidocaine, a common numbing medicine, into specific blood vessels in your head. The goal is to numb pain receptors that cause chronic headaches, which might reduce how often, how long, and how bad your migraines are. To join, you must be between 18 and 75 years old and have chronic daily headaches (more than 15 headache days a month for at least 3 months) that haven't improved with at least three other preventive treatments. The study aims to see if this treatment reduces your monthly migraine headache days over three months after the procedure. The current status of this study is unclear, and it plans to enroll 40 participants.

Study design
This is an interventional study that plans to enroll 40 participants. It is an observational study designed to gather data before and after the lidocaine procedure.
What's involved
If you meet the eligibility criteria at your first visit, you will be scheduled for the lidocaine procedure. The study will then track your migraine headache days from enrollment up to three months after the treatment.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for three months after the treatment to measure the reduction in monthly migraine headache days.

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NCT07061847

Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

Recruiting
PHASE2Ages 18–75InterventionalTreatment
Northwell Health
~40 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Lidocaine (drug)Lidocaine Procedure

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reduction in Monthly Migraine Headache Days
Measured over From enrollment to post-treatment at 3 months
Migraine
1 sites across 1 states
New York1

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  • Reduction in Monthly Migraine Headache DaysFrom enrollment to post-treatment at 3 months

    To observe a ≥50% reduction in monthly migraine headache days in one month post intra-arterial lidocaine infusion into the bilateral middle meningeal artery.