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Lung Cancer Screening for Family Members of Patients with Mutation-Driven Lung Cancer

This study is looking into whether lung cancer can be passed down in families and if we can find it early. It focuses on immediate family members (ages 40-80) of people who have lung cancer caused by a specific genetic change (driver mutation). If you join, you would receive a Low Dose CT Scan, which is a special X-ray to look for lung cancer. The main goal is to see how many lung cancers are found after two years. The study is currently recruiting and plans to include about 1753 people.

Study design
This is a single-armed screening study, meaning everyone receives the same intervention. It aims to enroll about 1753 participants.
What's involved
You would have one Low Dose CT Scan after your eligibility is confirmed. You would also complete a screening questionnaire.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, which is the number of lung cancers found, is measured at 2 years.

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NCT07062172

Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

Recruiting
NAAges 18–80InterventionalScreening
University of California, Irvine
~1,753 participants
Updated 2025-07-14 on ClinicalTrials.gov
What's tested:Low Dose CT Scan

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of lung cancers found
Measured over 2 years

Conditions

Lung Cancer
Driver Mutation

Explore related trials

Lung CarcinomaDeleterious Mutation

Where it's being run

1 sites across 1 states
California1

Who to contact

Chao Family Comprehensive Cancer Center University of California, Irvine
[email protected]
1-877-827-8839
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Current diagnosis of lung cancer with a driver mutation.
Known driver mutation (e.g. via NGS, PCR, IHC, FISH, RT-PCR etc.)
Able and willing to give informed consent.
Able and willing to complete the screening questionnaire.
Age 40 - 80.
Must have a first degree relative (mother, father, sibling, biological child) eligible for Cohort A. Note: Multiple first degree relatives of a Cohort A eligible participant may be approached for participation into the trial.
Smoked \< 20 pack years; a. Pack years = numbers of packs per day × number of years smoked; b. One pack year is the equivalent of smoking an average of 20 cigarettes (1 pack) per day for a year.
Be able to undergo a low dose chest CT scan.
If an upper respiratory infection (pneumonia, COVID19, flu, etc.) occurred in the last 3 months, this infection must have resolved by time of enrollment.
Able and willing to provide informed consent.
Able and willing to comply with the protocol requirements

Exclusion

Previous history of lung cancers.
Symptoms suggestive of presence of current lung cancer, including (but not limited to): unexplained weight loss of over 15 pounds within the last 12 months or unexplained hemoptysis.
Pregnant at time of enrollment.
History of any type of cancer within 5 years, with the exception of in situ carcinomas and non-melanoma skin cancers (if excised).
Current smoker.
Smoked ≥ 20 pack years.
Had a chest CT scan within 1 year of study entry.

What this trial measures

  • Number of lung cancers found2 years

    Determine the number of lung cancers found in low dose CT scans of first degree relatives of lung cancer patients with known driver mutations.