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Understanding CPAP Airflow and Rebreathing in Obstructive Sleep Apnea

This study aims to understand how different Continuous Positive Airway Pressure (CPAP) mask designs affect the air you breathe during sleep if you have Obstructive Sleep Apnea (OSA). Researchers will test varying levels of CPAP pressure (0, 5, or 10 cmH2O) and different mask exhaust port flows (35, 23, 18, 13, and 8 L/s). They will measure changes in the amount of oxygen you breathe in while awake and asleep to see how these settings impact rebreathing of exhaled air. You might be eligible if you are 21-70 years old, have moderate to severe OSA, and currently use or have used CPAP. The study plans to enroll 13 participants, but its current status is unclear.

Study design
This is an interventional study involving 13 participants with Obstructive Sleep Apnea. It will test different CPAP settings and mask exhaust port flows.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes will be measured through study completion, which is an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07062770

Assessment of Circuit Rebreathing During CPAP Therapy

Recruiting
NAAges 21–70Interventional
Brigham and Women's Hospital
~13 participants
Updated 2025-07-14 on ClinicalTrials.gov
What's tested:Continuous positive airway pressure (CPAP)Mask exhaust port flow

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in flow-adjusted average inspired oxygen fraction (FiO₂) during wake.
Measured over through study completion, an average of 1 year
+1 more outcome measured

Conditions

Obstructive Sleep Apnea (OSA)

Explore related trials

Obstructive Sleep Apnea

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Atqiya Aishah, PhD · PRINCIPAL_INVESTIGATOR · Harvard Medical School & Brigham and Women's Hospital

Who to contact

Atqiya Aishah, PhD
[email protected]
857 396 3808
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Moderate to severe OSA (AHI\>20)
Self-reported CPAP users or have previously used CPAP
Self-reported holding pressure of maximum 13 cmH2O (if known)
Age: 21-70
BMI: 18-40 kg/m2

Exclusion

Self-reported severe mouth-breathing
Requirement for nocturnal supplemental oxygen or other ventilatory support
Severe cardiovascular or pulmonary disease
Any unstable or acute medical condition
Any additional sleep disorder, including insomnia, except for OSA.

What this trial measures

  • Change in flow-adjusted average inspired oxygen fraction (FiO₂) during wake.through study completion, an average of 1 year

    Difference in FiO2 between 23L/s vs 13L/s exhaust flow at 5 cmH2O PAP.

  • Change in flow-adjusted average inspired oxygen fraction (FiO₂) during sleep.through study completion, an average of 1 year

    Difference in FiO2 between 23L/s vs 13L/s exhaust flow at 5 cmH2O PAP.