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Bioavailability of Tart Cherry Products

This study is looking at how well your body absorbs beneficial compounds from different tart cherry products. We're testing a Fruit Bar (Tart Cherry N185), a Powdered Drink (Vita Cherry Sport N1244), and a commercially available 100% tart cherry juice (CherryActive). We'll compare these to a placebo beverage (an inactive drink). The goal is to see how much of the tart cherry compounds (polyphenols) are in your blood after you consume these items. This research helps us understand if shelf-stable tart cherry products can deliver these compounds effectively. You can join if you are an active duty military personnel or civilian between 17 and 39 years old, in good health, and willing to follow all study instructions. The study is currently unclear on its recruitment status.

Study design
This is an interventional study with a planned enrollment of 15 participants. It will compare different tart cherry products against a control.
What's involved
You will consume different tart cherry products or a placebo. Blood samples will be taken at baseline and at several time points up to 24 hours after consumption.
Compensation
Not stated in the trial record.
Follow-up
Your polyphenol levels will be measured for up to 24 hours after consuming the products.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07063173

Bioavailability of Ration Items Containing Tart Cherry Extract

Recruiting
NAAges 17–39Interventional
United States Army Research Institute of Environmental Medicine
~15 participants
Updated 2025-12-29 on ClinicalTrials.gov
What's tested:Fruit BarPowdered DrinkCommercially available 100% tart cherry juicePlacebo beverage

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postprandial concentrations of polyphenols in plasma
Measured over Baseline and postprandially @ 30-minutes, 60-minutes, 120-minutes, 240-minutes, 360-mins, 24 hours

Conditions

Bioavailability

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Healthy Volunteers

NCT07063173

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • USARIEM

    Natick, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Tracey Smith, PhD · PRINCIPAL_INVESTIGATOR · United States Army Research Institute of Environmental Medicine

Who to contact

Tracey J Smith, PhD
[email protected]
5082062390 · ext. 2390
Email the study team

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Eligibility criteria

Inclusion

Active duty military personnel and civilians will be invited to participate in the study if they:
Are between the ages of 18 (or 17 for military personnel) and 39.
Are willing to participate in all study procedures and comply with all study instruction.
In good health as determined by OMSO (Office of Medical Support and Oversight).
Supervisor approval for federal civilian employees and non-HRV active-duty military personnel stationed at NSSC

Exclusion

• Unable to understand verbal or written instructions or testing materials in English.
Have a bleeding disorder (e.g., von Willebrand Disease, hemophilia) or are being treated with medication that will impair blood clotting (for example, coumadin)
Have a history of GI-related conditions that may impact macronutrient absorption (e.g., Crohn's disease, ulcerative colitis, Celiac's disease or gluten sensitivity, bariatric surgery or gastroparesis, short bowel, inflammatory bowel disease, etc…);
Any use of antibiotics or antifungal, except topical antibiotics/antifungals within 3 months of study participation.
Colonoscopy within 3 months of study participation.
Regular (i.e., weekly or more frequent) use of over-the-counter medications (including antacids, laxatives, stool softeners, and antidiarrheals) unless approved by OMSO and study PI.
Are habitually taking nonsteroidal anti-inflammatory drugs (e.g., Advil, aspirin), corticosteroids (e.g., prednisone) or immunosuppressants (e.g. Humira);
Have an allergy or aversion (extreme dislike) to any of the test foods(e.g., cherry flavored beverages or bar). Allergy symptoms may include anaphylaxis, hives or eczema, tingling/itching in the mouth, dizziness or fainting, diarrhea, nausea or vomiting, swelling of the lips, face, tongue and throat).
Have donated blood within the past 8 weeks of the first test session or plan to donate blood during the study.
Are not willing to abstain from tobacco products and vigorous exercise for at least 24 hours" before each trial and consume a low-polyphenol diet two days prior to each test session and on the day of the test session.

What this trial measures

  • Postprandial concentrations of polyphenols in plasmaBaseline and postprandially @ 30-minutes, 60-minutes, 120-minutes, 240-minutes, 360-mins, 24 hours

    The primary objective of this study is to evaluate the postprandial concentrations of: * nmol/L for anthocyanins \& anthocyanidins (cyanidin-3-glucosylrutinoside, cyanidin-3-rutinoside,cyanidin-3-sophoroside, cyanidin-3-glucoside, cyanidin, peonidin-3-glucoside and pelargonidin); * µmol/L for flavonols (Isorhamnetin-3-rutinoside, kaemperol, and que after consuming a TCP-containing, shelf-stable bar and shelf-stable powdered drink (compared to a non-TCP containing control and a TC-containing commercial item).