NCT07064941
Effect of Exercise on Body Composition and Bone Health in Patients With Thalassemia
Active, Not Recruiting
NAAges 14–40InterventionalTreatmentUniversity of California, San FranciscoInvestigator-initiated
~20 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Exercise
At a glance
Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Body Lean Mass (grams)
Measured over 12 weeks (Period 1) and 36 weeks (Period 2)
+1 more outcome measured
Conditions
Where it's being run
2 sites across 1 statesCalifornia2
Study leadership
- Ellen Fung, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
Age: 14 - 40 years
BMD Z-score at any skeletal site \< -1.0
Diagnosed with thalassemia (any genotype, regardless of transfusion dependency)
Vitamin D (25-Hydroxy) drawn within the previous 12 months \>20 ng/mL
English speaking, able to consent
Exclusion
Patients who self-identify as 'exercisers' e.g. routinely exercise for minimum of 45 min/day, 5x/week
Pregnant (unable to conduct bone density measurements in pregnant females)
Hypogonadal, must be on replacement sex hormone therapy for min of 6 months
Cardiac T2\* by Magnetic Resonance Imaging of \<20 ms (e.g. evidence of cardiac iron overload)
Recent long bone or vertebral fracture (within the last 6 months)
Cognitive impairment limiting ability to understand instructions during orientation
Other conditions known to influence bone health or body composition as determined by the investigator
Patients at risk for cardiovascular disease yet have not received a routine cardiology assessment within the previous 12 months
Bone medication (e.g. Zometa, Prolia, Forteo) use in previous 2 years
What this trial measures
- Total Body Lean Mass (grams)12 weeks (Period 1) and 36 weeks (Period 2)
Total body lean mass assessed by Dual Energy X-Ray Absorptiometry (DXA)
- Percentage Body Fat12 weeks (Period 1) and 36 weeks (Period 2)
Percentage body fat assessed by Dual Energy X-Ray Absorptiometry (DXA)