Observational Study: Imaging Inflammatory Cells in Uveitis Using OCT

This study aims to improve how doctors count and identify different types of cells and proteins in your eye if you have anterior uveitis. Anterior uveitis is a condition where the front part of your eye becomes inflamed, often due to other health issues. Researchers will use a special high-resolution imaging device called optical coherence tomography (OCT) to see if it can provide a clear, standard way to measure these cells. This is an observational study, meaning you won't receive a new treatment. Instead, researchers will gather information from your existing care. The study is looking for 125 participants between 5 and 85 years old who have active inflammation from various types of uveitis, including those linked to conditions like juvenile idiopathic arthritis (JIA) or herpes simplex virus (HSV). The main goal is to identify and measure these cells on the first day of the study.

Study design
This is an observational study with a planned enrollment of 125 participants. It is not a randomized trial and does not specify a phase.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, identification and measurement of anterior chamber cells, is measured at Day 1.

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NCT07065747

Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

Recruiting
Not specifiedAges 5–85Observational
Oregon Health and Science University
~125 participants
Updated 2025-07-17 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identification & Measurement of Anterior Chamber Cells
Measured over Day 1
Anterior Uveitis (AU)
Birdshot Chorioretinitis
Behcet Disease
Herpes Simplex Virus
Juvenile Idiopathic Arthritis (JIA)
Spondyloarthritis (SA)
Sarcoidosis
Posterior Vitreous Detachment
1 sites across 1 states
Oregon1
  • Yan Li, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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  • Identification & Measurement of Anterior Chamber CellsDay 1

    Anterior Chamber (AC) cells will be identified from OCT images by computer algorithms. AC cell number counted by OCT will be correlated with slit lamp grading. Cell size \& other characteristics identified from OCT images will be associated with different uveitis diagnostic categories. The Standardization of Uveitis Nomenclature (SUN) grading system (scale: 0 = none to 4+ = severe) will be used to compare OCT-derived quantification against slit-lamp grading performed by attending physicians.