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Cannabidiol (CBD) and Stress Response Study

This study is looking at how regular use of cannabidiol (CBD) affects your body's response to stress. Researchers want to understand the biological and psychological ways CBD might change how you react to stressful situations. You might be able to join if you are a healthy adult between 21 and 70 years old, have a normal sleep schedule, and either use CBD daily/regularly or do not use it regularly. The study will measure changes in your feelings (like stress and anxiety), heart activity, and cortisol (a stress hormone) after a stressful event to see if CBD has an effect. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 125 participants. It compares the stress responses of adults who regularly use CBD with those who do not.
What's involved
You will prepare and deliver a speech in front of evaluators and a video recorder as part of a stress intervention. Your subjective states, cardiovascular activity, and cortisol will be measured at 2.5 hours.
Compensation
Not stated in the trial record.
Follow-up
Your subjective states, cardiovascular activity, and cortisol will be measured at 2.5 hours after the stress intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07069478

Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

Recruiting
NAAges 21–70InterventionalBasic science
University of Minnesota
~125 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Stress Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in subjective states (stress, anxiety, positive affect)
Measured over 2.5 hours
+1 more outcome measured

Conditions

CBD
Cannabidiol
Stress
Acute Stress Reaction

Explore related trials

Stress

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Mustafa al'Absi · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

Stress and Resilience Research Labs
[email protected]
2187268623
Email the study team

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Eligibility criteria

Inclusion

Adults who are relatively healthy and aged 21-70 years.
Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion

Participated in previous acute stress studies that included a similar stress induction.
Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
Self-reported current pregnancy.
Self-reported current use of illicit substances (other than cannabis).
Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
Students of the principal researcher

What this trial measures

  • Change in subjective states (stress, anxiety, positive affect)2.5 hours

    Participants will self-report the extent to which they have felt stressed, overwhelmed, anxious/nervous, cheerful, and happy during the last 30 minutes before acute stress, immediately after acute stress, and after a recovery period. The Subjective States Questionnaire will be used to score responses. The minimum values are 0 (not at all) and the maximum values are 7 (very strongly). Higher scores mean more stress, more anxiety, and more positive affect.

  • Change in cardiovascular activity and cortisol2.5 hours

    Saliva will be collected (for later cortisol assays) and cardiovascular activity will be measured before, during, and after acute stress.