Back to search results

Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) Trial

This study, called EVENT ALS, is looking at the best time to start non-invasive ventilation (NIV) for people with Amyotrophic Lateral Sclerosis (ALS). NIV is a machine that helps you breathe using a mask. While NIV can improve quality of life and survival for people with ALS, doctors don't yet know the ideal time to start it. This trial will start NIV earlier than current U.S. guidelines. Researchers want to see if starting NIV sooner helps people with ALS. You might be able to join if you are 18 or older, have been diagnosed with ALS in the last six months, and have not used NIV before. The main goal is to see how long it takes for participants to start using NIV, with follow-up for about one year.

Study design
This is an interventional study with a planned enrollment of 48 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for approximately one year after enrollment to measure the time to their first use of non-invasive ventilation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07071935

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Pennsylvania
~48 participants
Updated 2026-06-26 on ClinicalTrials.gov
What's tested:Non-invasive ventilation

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time to first use of non-invasive ventilation
Measured over From enrollment to end of follow-up at approximately 1 year

Conditions

Amyotrophic Lateral Sclerosis (ALS)
Chronic Respiratory Failure
Neuromuscular Disease Patients
Neuromuscular Disease
Respiratory Insufficiency
Respiratory Insufficiency Requiring Mechanical Ventilation
Positive Pressure Ventilation
Non-invasive Ventilation
Non-invasive Ventilation Support
Non-invasive Ventilatory Support

Explore related trials

Amyotrophic Lateral Sclerosis

NCT07071935

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Penn Comprehensive ALS Center at Pennsylvania Hospital

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

  • Penn State Hershey ALS Clinic

    Hershey, Pennsylvaniastudy coordinator listed

    Recruiting

  • Thomas Jefferson University Weinberg ALS Center

    Philadelphi, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jason T Ackrivo, MD, MSCE · PRINCIPAL_INVESTIGATOR · Perelman School of Medicine at the University of Pennsylvania

Who to contact

Jason T Ackrivo, MD, MSCE
[email protected]
215-829-3053
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Diagnosed with ALS using the Gold Coast Criteria within the last 6 months
Age ≥18 years
Willingness and ability to participate in study procedures
Provision of signed and dated informed consent form

What this trial measures

  • Time to first use of non-invasive ventilationFrom enrollment to end of follow-up at approximately 1 year

    Number of days between randomization to first recorded overnight usage of non-invasive ventilation according to ventilation device data download.