Observational Study of LEMS in Small Cell Lung Cancer

This study is looking at how often Lambert-Eaton Myasthenic Syndrome (LEMS) occurs in people who have small cell lung cancer (SCLC). LEMS is a rare disorder that affects the connection between nerves and muscles, causing muscle weakness. Researchers want to find out how many SCLC patients show signs of LEMS. You can join if you are an adult diagnosed with SCLC and are willing to share your medical information. The study will consider it a "success" if it can identify how many participants develop suspicious LEMS within one year. This is an observational study, meaning no specific treatments are being tested, and the current recruitment status is unclear.

Study design
This is a multi-center observational study planning to enroll 400 participants with small cell lung cancer.
What's involved
You would undergo a brief neurological evaluation and blood tests (VGCC antibody testing) every three months. If you show signs of LEMS and have positive antibody tests, your participation would end.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is to measure suspicious LEMS at 1 year. If you meet the criteria for suspicious LEMS, your study participation will end at that point.

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NCT07075627

A Study to Evaluate the Incidence of Clinically Suspicious Lambert-Eaton Myasthenic Syndrome (LEMS) in Subjects Diagnosed With Small Cell Lung Cancer (SCLC)

Withdrawn
Not specifiedAges 18+Observational
Addario Lung Cancer Medical Institute
Updated 2026-08-04 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Suspicious LEMS
Measured over 1 year
Small Cell Lung Cancer ( SCLC )
Lambert Eaton Myasthenic Syndrome (LEMS)
1 sites across 1 states
Massachusetts1
  • Jacob Sands, MD · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute
  • Gilbert Youssef, MD · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Suspicious LEMS1 year

    Incidence of clinically suspicious LEMS diagnosis