Observational Study of Phage Treatment for NTM and Other Infections

This study is looking for adults aged 18 and older who have a bacterial or mycobacterial infection, especially Nontuberculous Mycobacterial (NTM) Lung Disease, that needs treatment. The goal is to understand how people respond to bacteriophage treatment (a type of therapy that uses viruses to kill bacteria). Researchers will collect blood and airway samples during follow-up visits from people who are considering or receiving bacteriophage treatment. They will compare samples from those who receive treatment with those who don't, to find out what changes in the body (like in the airway microbiome or immune response) are linked to improvement. The study plans to enroll 100 participants, but its current status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information from 100 participants. It is not specified if participants will be randomly assigned to groups.
What's involved
Blood and airway samples will be obtained during follow-up visits. The duration of these visits or the total number of visits is not specified.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 2 years to measure biomarkers associated with clinical, radiographic, or culture improvement.

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NCT07076238

Biomarkers of Phage Treatment Response in NTM and Other Infections

Recruiting
Not specifiedAges 18+Observational
NYU Langone Health
~100 participants
Updated 2025-10-30 on ClinicalTrials.gov
What's tested:Bacteriophage Treatment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Biomarkers associated with clinical and/or radiographic improvement and/or culture improvement
Measured over End of study (up to 2 years)
Nontuberculous Mycobacterial Lung Disease
1 sites across 1 states
New York1
  • Doreen Addrizzo-Harris, MD, FCCP · PRINCIPAL_INVESTIGATOR · NYU Langone Health

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  • Biomarkers associated with clinical and/or radiographic improvement and/or culture improvementEnd of study (up to 2 years)

    Improvement includes clearing of cultures or decrease in qualitative or resolution of signs and symptoms of infection after at least 6-8 weeks of bacteriophage therapy.