Probiotic Supplementation for Iron Status in Pregnancy

This study is looking at whether a probiotic called Lactiplantibacillus plantarum 299v can help improve iron levels in pregnant women. Many pregnant women experience iron deficiency (low iron) or iron deficiency anemia (low iron leading to low red blood cells), which can cause health problems for both mother and baby. Current iron supplements often cause stomach upset, making it hard for women to take them regularly. This study aims to find a better way to manage iron levels. You might be able to join if you are 18-45 years old, 10-16 weeks pregnant with one baby, and at risk for iron deficiency. Researchers will measure your hemoglobin (a protein in red blood cells that carries oxygen) levels at different points during your pregnancy and at delivery to see if the probiotic helps. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 250 pregnant women. Participants will receive either the probiotic Lactiplantibacillus plantarum 299v or a placebo capsule.
What's involved
Your hemoglobin levels will be measured at 10-16 weeks, 22-28 weeks, and 30-36 weeks of pregnancy, and again at delivery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed until delivery, with measurements taken at four specific time points during pregnancy and at delivery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07076849

Probiotic Supplementation in Optimizing Iron and Hematological Status Among Pregnant Females

Recruiting
PHASE2Ages 18–45InterventionalPrevention
University of Illinois at Chicago
~250 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Lactiplantibacillus plantarum 299vPlacebo Capsule(s)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maternal hemoglobin from complete blood count (CBC) with differential
Measured over 10-16 weeks GA (V1), 22-28 weeks GA (V2), 30-36 weeks GA (V3), delivery (V4)
Iron Deficiency (ID)
Pregnancy

NCT07076849

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Illinois at Chicago

    Chicago, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

singleton naturally conceived pregnancy;
at risk of IDA \[Hb 11.0 - 11.9 g/dL (first trimester) and Hb 10.5 - 11.5 g/dL (second trimester) based on new OB clinical complete blood count (CBC) results obtained from the EHR;
18 - 45 years old;
10-16 weeks GA;
fluency in English to provide consent and complete study procedures;
ability to provide consent;
and ownership of a smartphone (currently more than 90% of our patient population at the CWH).

Exclusion

IDA or other nutritional anemia (i.e., diagnosed or suspected B12 or folate deficiency) based on new OB blood work that includes MCV and MCH to characterize the anemia;
recent blood transfusion;
autoimmune disorder (e.g., rheumatoid arthritis);
inflammatory bowel disease;
oral or IV antibiotic use within 2 months;
previous spontaneous preterm birth;
history of bariatric surgery;
malabsorptive disease;
current hyperemesis;
current eating disorder;
hematologic disorder or trait carrier (e.g., hemochromatosis, β-thalassemia);
current tobacco, alcohol or illicit drug use (Excluding marijuana).
  • Maternal hemoglobin from complete blood count (CBC) with differential10-16 weeks GA (V1), 22-28 weeks GA (V2), 30-36 weeks GA (V3), delivery (V4)

    Venous blood draw