Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
This study is looking at how quitting smoking might affect pain in Native American adults. Researchers want to see if a program that helps people stop smoking, using financial rewards for staying smoke-free, can improve how the body handles pain. They will measure changes in pain inhibition (how well your body blocks pain signals) and spinal reflexes related to pain, as well as overall stress on the body (allostatic load). You might be able to join if you are a Native American adult, smoke daily, have a smartphone, and can read and speak English. The goal is to understand if quitting smoking can reduce the risk of chronic pain in this community.
- Study design
- This is an interventional study planning to enroll 150 participants. It is not specified if it is randomized or blinded.
- What's involved
- Participants will receive a smoking cessation treatment with financial incentives. Measurements will be taken at the start of the study and after 4 weeks of treatment plus 4 weeks of verified smoking abstinence.
- Compensation
- Investigators will provide financial incentives for biochemically verified abstinence at 4 weeks following treatment.
- Follow-up
- Participants will be followed for 4 weeks after treatment, plus 4 weeks of verified smoking abstinence.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jamie L Rhudy, PhD · PRINCIPAL_INVESTIGATOR · University of Oklahoma Health Sciences
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Pain inhibitionBaseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence)
Pain inhibition will be assessed using a conditioned pain modulation task with cold water as the conditioning stimulus and electric stimulations as the test stimulus.
- Inhibition of pain-related spinal reflexBaseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence)
Pain-related spinal reflex inhibition assessed from electromyogram will be assessed using a conditioned pain modulation task with cold water as the conditioning stimulus and electric stimulations as the test stimulus.
- Allostatic loadBaseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence)
A single latent variable for allostatic load will be created using principal components analysis to combine cardiovascular (i.e., resting blood pressure and heart rate and fasting lipid profile \[HDL, LDL, total cholesterol, and triglycerides\]), metabolic (i.e., BMI, waist-to-hip ratio, HbA1c), immune (i.e., hs-CRP), and parasympathetic (i.e., resting heart rate variability) variables.
- Pain amplificationBaseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence)
Pain amplification will be assessed by capsaicin (substance from hot chili peppers) pain model. Pain amplification is defined as the area of skin (in cm squared) surrounding the site of capsaicin application that shows higher pain relative to the untreated skin.