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Bone Health and Frailty in Older Women with Sickle Cell Trait

This study is looking at how sickle cell trait (SCT) might affect bone health, muscle function, and frailty in women aged 50 and older who have gone through menopause and are of African descent. Researchers want to see if women with SCT have weaker bones or more frailty compared to women without SCT. You don't need to know if you have SCT to join, as this will be checked during the study. The study plans to enroll 50 women. The main goal is to compare bone mineral density between women with and without sickle cell trait.

Study design
This is an observational study comparing 25 women with sickle cell trait to 25 women without it. It is not a treatment study.
What's involved
Participants will donate blood for various tests and undergo a bone density and muscle mass measurement using a DEXA scan.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, bone mineral density, is measured at Day 1, suggesting a single visit for data collection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07083531

Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

Recruiting
Not specifiedAges 50+Observational
UConn Health
~50 participants
Updated 2025-07-24 on ClinicalTrials.gov
What's tested:Healthy volunteers without SCTHealthy volunteers with SCT

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in bone mineral density between older African descent (AD) women with (N=25) and without (N=25) sickle cell trait (SCT)
Measured over Day 1

Conditions

Sickle Cell Disease
Sickle Cell Trait

Explore related trials

Sickle Cell DiseaseSickle Cell Trait

NCT07083531

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UConn Health

    Farmington, Connecticutstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Biree Andemariam, MD · PRINCIPAL_INVESTIGATOR · UConn Health

Who to contact

Zoe Green, BS
[email protected]
860.679.4656
Email the study team

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Eligibility criteria

Inclusion

Female of African Decent.
Age 50 years or older.
Lack of menstrual period for at least 12 consecutive months

Exclusion

Taking medications known to influence bone metabolism (e.g., glucocorticoids, hormonal therapy, cancer or chemotherapy meds, anti-resorptive medications or anabolic therapies).
Known metabolic bone disorder (e.g., uncontrolled thyroid disease, hyperparathyroidism, Vitamin D deficiency)
Taking an investigational drug
Documented sickle cell disease

What this trial measures

  • Difference in bone mineral density between older African descent (AD) women with (N=25) and without (N=25) sickle cell trait (SCT)Day 1

    Particpants will undergo dual energy xray absorptiometry.