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Observational Study on Aspirin and Craniotomy Bleeding

This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery for a cerebral aneurysm (a weak, bulging spot on a blood vessel in the brain). Aspirin can prevent blood clots but also increase bleeding risk. Doctors need to know if patients should stop aspirin before surgery. Researchers will observe 100 patients, some who take low-dose aspirin (75-100 mg) daily and some who don't, before elective craniotomy (brain surgery). They will collect information on bleeding during surgery and after, through blood tests and CT scans. This study aims to help doctors make better decisions about aspirin use for patients undergoing this type of surgery.

Study design
This is an observational study involving 100 participants. Researchers will observe patients who are already taking aspirin or not, without changing their treatment.
What's involved
Participants will undergo elective craniotomy for a cerebral aneurysm. Researchers will collect information about bleeding during surgery, blood test results, and CT scans after surgery.
Compensation
Not stated in the trial record.
Follow-up
Postoperative hemorrhage rate will be measured at 48 hours after surgery. Intraoperative blood loss is measured from the start to the end of surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07086183

Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy

Not Yet Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~100 participants
Updated 2026-01-07 on ClinicalTrials.gov
What's tested:Observation

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postoperative Hemorrhage Rate
Measured over 48 hours postoperatively
+1 more outcome measured

Conditions

Aneurysm Cerebral

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Cerebral Aneurysm

NCT07086183

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Burdenko National Medical Research Center of Neurosurgery

    Moscow, Russiastudy coordinator listed

  • Mayo Clinic Florida

    Jacksonville, Floridastudy coordinator listed

  • Sapienza University of Rome

    Roma, Italystudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Shaun Gruenbaum, MD, PhD
[email protected]
904-953-2000
Email the study team

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Eligibility criteria

Inclusion

Age \> or = 18 years old
Patients willing to participate and provide an informed consent
Patients undergoing elective craniotomy for cerebral aneurysm clipping
Patients on chronic low-dose (75-100 mg) aspirin daily (aspirin group) or not on aspirin therapy for at least 7 days (control group) preoperatively.

Exclusion

Emergency craniotomy
Use of other antiplatelet or anticoagulant medications within 7 days prior to surgery
Known bleeding disorders (e.g. hemophilia, thrombocytopenia)
History of intracranial hemorrhage unrelated to aneurysm
Inability to provide informed consent

What this trial measures

  • Postoperative Hemorrhage Rate48 hours postoperatively

    The incidence of postoperative hemorrhage detected on CT scans within 48 hours after surgery.

  • Intraoperative Blood LossFrom start to end of surgery

    Measured by the change in hemoglobin and hematocrit levels from preoperative baseline to immediate postoperative period.