Cocaine and Pentoxifylline Study for Cocaine Use Disorder

This study is looking at how a medication called pentoxifylline affects the impact of cocaine in people with Cocaine Use Disorder. Researchers will give participants either pentoxifylline, cocaine, or a placebo (an inactive substance) to see their effects. The main goal is to understand how cocaine's reinforcing effects (how much someone wants to use it again) are changed by pentoxifylline. You may be able to join if you are 18-55 years old, speak English, are not currently seeking treatment for drug use, and have recently used cocaine. The study plans to enroll 30 participants, but its current status is unclear.

Study design
This is an interventional study planning to enroll 30 participants. It will compare the effects of pentoxifylline, cocaine, and a placebo.
What's involved
You would be admitted to an inpatient facility for approximately one month. During this time, researchers will measure the reinforcing effects of cocaine at 9 different times.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for approximately one month during their inpatient admission.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07086794

Cocaine and Pentoxifylline (BED IN 47)

Recruiting
EARLY_PHASE1Ages 18–55InterventionalBasic science
William Stoops
~30 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:PlaceboCocaine (IV)Pentoxifylline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reinforcing Effects of Cocaine
Measured over 9 times over approximately 1 month inpatient admission
Cocaine Use Disorder

NCT07086794

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Psychopharmacology of Addiction Laboratory

    Lexington, Kentuckystudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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  • Reinforcing Effects of Cocaine9 times over approximately 1 month inpatient admission

    Number of Times Subjects Choose Cocaine (Maximum of 5 Choices) Over Money