CPAP for Atrial Fibrillation and Sleep Apnea (SPARTA)

This study is looking at whether using a CPAP (Continuous Positive Airway Pressure) machine can help reduce atrial fibrillation (AFib) in people who also have moderate to severe obstructive sleep apnea (OSA). You might be able to join if you are 18-85 years old, have AFib that occurs often, and have moderate to severe OSA. You also need to have an implanted heart device that monitors your heart rhythm and be enrolled in remote monitoring. The study will measure the change in how much AFib you experience over about 13 weeks. The current recruitment status is unclear.

Study design
This is a pilot N-of-1 randomized crossover study, meaning each of the 20 participants will try both CPAP and no CPAP at different times. It is designed to help plan a larger study.
What's involved
You would use CPAP for 2 weeks, then stop for 2 weeks, repeating this cycle for a total of 12 weeks. Your AFib episodes will be tracked by your implanted device, and you will complete a questionnaire about your quality of life.
Compensation
Not stated in the trial record.
Follow-up
Your participation will last up to 13 weeks, which is the duration of the study's primary endpoint measurement.

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NCT07087587

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Recruiting
NAAges 18–85InterventionalTreatment
The Cleveland Clinic
~20 participants
Updated 2026-04-13 on ClinicalTrials.gov
What's tested:CPAP

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Average Daily AF Burden (%)
Measured over Up to 13 weeks (duration of each patient's participation)
Afib
Sleep Apnea Syndrome, Obstructive
CPAP
2 sites across 2 states
Ohio1
Washington1

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  • Change in Average Daily AF Burden (%)Up to 13 weeks (duration of each patient's participation)

    Percentage change in average daily atrial fibrillation burden, measured via implantable device data, comparing CPAP and non-CPAP periods.