Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy Loss

This study is comparing two surgical procedures for early pregnancy loss (a pregnancy not developing properly before 12 weeks and 6 days). The first procedure is hysteroscopic resection, where a camera is used to see inside the uterus and remove the pregnancy loss. The second is manual vacuum aspiration, where the pregnancy loss is suctioned out using a hand-held pump with ultrasound guidance. The study aims to see which method leads to a faster decrease in beta human chorionic gonadotropin (bHCG) levels, a hormone measured in blood tests. You may be able to join if you are a woman between 18 and 55 years old, have an ultrasound diagnosis of early pregnancy loss (under 9 weeks gestational age), and are willing to follow all study procedures. The study plans to enroll 80 participants, but its current recruitment status is unclear.

Study design
This is an interventional study comparing two surgical procedures. It plans to enroll 80 participants.
What's involved
You would undergo either hysteroscopic resection or manual vacuum aspiration. You would also have blood tests at baseline, and then 1, 2, 3, 4, and 5 weeks after your operation.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 5 weeks after their operation to measure bHCG levels.

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NCT07088510

Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy

Recruiting
NAAges 18–55InterventionalTreatment
University Hospitals Cleveland Medical Center
~80 participants
Updated 2025-07-30 on ClinicalTrials.gov
What's tested:Hysteroscopic resectionManual Vacuum Aspiration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in beta human chorionic gonadotropin (bHCG) levels as measured by blood test
Measured over Baseline, 1 week post operation, 2 week post operation, 3 week post operation, 4 week post operation, 5 week post operation
Miscarriage in First Trimester
1 sites across 1 states
Ohio1
  • Joseph Findley, MD · PRINCIPAL_INVESTIGATOR · University Hospitals
  • Archana Ayyar, MD · PRINCIPAL_INVESTIGATOR · University Hospitals

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Eligibility criteria

Inclusion

Adult women age 18-55
Ultrasound Diagnosis of Early Pregnancy Loss
\< 9 weeks gestational age as determined by ultrasound
Singleton non-viable pregnancy
Stated and willingness to comply with all study procedures and availability for the duration of the study
Provision of signed and dated informed consent form
Chose a surgical method of management for fetal loss

Exclusion

Pregnancy of Unknown Location
Current, viable pregnancy
Prior medical treatment for this early pregnancy loss
Contraindications to surgical management
Active infection (i.e. fever, chills, fundal tenderness)
Pre-existing coagulopathies
  • Change in beta human chorionic gonadotropin (bHCG) levels as measured by blood testBaseline, 1 week post operation, 2 week post operation, 3 week post operation, 4 week post operation, 5 week post operation