A Study of Dotinurad Versus Allopurinol in Tophaceous Gout

This study is comparing two medications, dotinurad and allopurinol, for adults with tophaceous gout (a type of gout with visible lumps of uric acid crystals). Researchers want to see how well dotinurad lowers serum uric acid (sUA) levels compared to allopurinol after 24 weeks. To join, you must be between 18 and 75 years old, have had gout for at least one year, and have at least one measurable tophus on your hands, wrists, feet, or ankles. The study aims to enroll 250 participants, but its current recruitment status is unclear.

Study design
This interventional study is comparing dotinurad to allopurinol in 250 participants. The phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at Week 24, indicating follow-up for at least that duration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07089888

A Study of Dotinurad Versus Allopurinol in Tophaceous Gout

Recruiting
PHASE3Ages 18–75InterventionalTreatment
Crystalys Therapeutics
~250 participants
Updated 2026-07-30 on ClinicalTrials.gov
What's tested:AllopurinolDotinurad

At a glance

Recruiting sites
77 of 89 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of Participants with an sUA Level <5.0 mg/dL at Week 24
Measured over Week 24
Tophaceous Gout
89 sites across 28 states
Texas17
California13
Florida13
Michigan5
Arizona4
Alabama3
Louisiana3
North Carolina3

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  • Percentage of Participants with an sUA Level <5.0 mg/dL at Week 24Week 24