This study is testing a drug called iloperidone to see if it can safely and effectively lower blood pressure in people with uncontrolled hypertension (high blood pressure). Uncontrolled hypertension means your blood pressure is still high even after taking at least one blood pressure medication for over eight weeks. You might be able to join if you are between 18 and 65 years old and have a specific blood pressure reading (SiSBP of 130 mmHg or higher). However, you cannot join if you have very severe high blood pressure, unstable heart problems, or kidney issues. The study will compare iloperidone to a placebo (an inactive substance) to see how much it changes your blood pressure after four weeks.

Study design

This is a multicenter, randomized, double-blind, placebo-controlled study, meaning participants are randomly assigned to receive either iloperidone or a placebo, and neither you nor your doctor will know which you are receiving. It plans to enroll 240 participants.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint measures changes in blood pressure up to treatment week 4, but long-term follow-up beyond this is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.