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Cocaine Cue-reactivity Incubation Study

This study is looking at how the brain reacts to cocaine-related cues (triggers) in people with Cocaine Use Disorder (CUD). Researchers want to see if a technique called Cognitive Reappraisal (CR), which helps you change how you think about things, can reduce these reactions. They will track brain activity and behavior using special measurements over time. The goal is to understand if CR helps people with CUD during abstinence and if these brain and behavior changes are linked to better outcomes. The study is currently unclear on its recruitment status and plans to enroll 252 participants. You might be able to join if you are 18-65 years old, have a diagnosis of CUD, and are seeking treatment.

Study design
This interventional study plans to enroll 252 participants. It involves comparing Cognitive Reappraisal with a control cue-reactivity task.
What's involved
Participants will complete a Cognitive Reappraisal task or a control cue-reactivity task. Brain activity will be measured at less than 2 months, 3 months, and 5 months after starting abstinence.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for at least 5 months after starting abstinence.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07091877

Cocaine Cue-reactivity Incubation Study

Recruiting
NAAges 18–65InterventionalBasic science
Icahn School of Medicine at Mount Sinai
~252 participants
Updated 2025-07-29 on ClinicalTrials.gov
What's tested:Cognitive ReappraisalControl cue-reactivity task

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Late Positive Potential (LPP) amplitude
Measured over <2 months, 3 months, and 5 months after abstinence initiation

Conditions

Cocaine Use Disorder

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Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Icahn School of Medicine at Mount Sinai

    New York, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Muhammad A Parvaz, PhD · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

Who to contact

Muhammad A Parvaz, PhD
[email protected]
212-241-3638
Email the study team

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Eligibility criteria

Inclusion

Ability to understand and give informed consent
Age 18-65
DSM-5 Diagnosis of CUD (Cocaine Use Disorder)
Have appropriate abstinence duration (i.e., \<2 months) at the first visit.
Must be seeking treatment for CUD (at the first visit)

Exclusion

DSM-5 diagnosis for other psychiatric illnesses (other than mood and anxiety disorders that are highly comorbid with substance use disorders)
Urine positive for any psychoactive drugs (e.g., cocaine, methamphetamine, cannabis, opiates, benzodiazepines, etc.) at baseline
Head trauma with loss of consciousness
History of neurological diseases, including seizures
Thick and/or non-removable hair braids that present difficulty for EEG electrode-scalp contact

What this trial measures

  • Change in Late Positive Potential (LPP) amplitude<2 months, 3 months, and 5 months after abstinence initiation

    EEG-derived Late Positive Potential (LPP) amplitude will be measured while participants view cocaine-related cues. Higher amplitudes indicate greater cue reactivity.