NCT07092605

Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures

Enrolling by Invitation
EARLY_PHASE1Ages 18–65InterventionalTreatment
AgelessRx
~150 participants
Updated 2025-07-30 on ClinicalTrials.gov
What's tested:GLP-1Placebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in self-reported pain levels in participants microdosing GLP1s
Measured over 6 months
+7 more outcomes measured
Longevity
Quality of Life
Mood
Inflammation
Immune Health
Pain Management
Weight Management
Alertness
1 sites across 1 states
Michigan1

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

New or existing AgelessRx patient
Adults (aged 18-65)
Any sex
Any ethnicity
BMI ≥ 20 kg/m\^2
Interest in taking microdoses of semaglutide for health and longevity improvement with no intent to seek weight loss improvement.

Exclusion

Individuals who are denied a longevity product by the AgelessRx medical team will not be asked to participate in any product specific test(s) or questionnaire(s)
History of bariatric surgery
Use of other weight-loss medications currently or within the past 6 months
Contraindications to semaglutide
Significant psychiatric illness that may affect participation
Pregnant or breastfeeding individuals
  • Change in self-reported pain levels in participants microdosing GLP1s6 months

    Participants will complete an extensive medical questionnaire every 4 weeks over a 24-week period to monitor self-reported pain levels

  • Concentration of complete blood cells, as a measure of immunological health, in participants microdosing GLP1s6 months

    CBC panel will be analyzed every 12 weeks over a 24-week period, reported in thousands of cells per microliter with the change from baseline reported as percent deviation and compared to normalized range of healthy individuals

  • Concentration of basic metabolites (cholesterol, glucose, creatinine, sodium, potassium), as a measure of immunological health, in participants microdosing GLP1s6 months

    BMP panel will be analyzed every 12 weeks over a 24-week period, reported in mg/dL with the change from baseline reported as percent deviation and compared to a normalized range of healthy individuals

  • Change in mood in participants microdosing GLP1s6 months

    Mood will be assessed every 4 weeks over a 24-week period using the SF-36 standardized questionnaire with deviation reported as percent change from baseline

  • Change in heart rate variability in participants microdosing GLP1s6 months

    Participants will wear health devices with data monitored every 4 weeks over a 24-week period to observe change in heart rate variability, being defined as the variability of a participant's resting heart rate. Variability will be measured as an average deviation from baseline heart rate at each timepoint and reported as percent difference.

  • Changes in sleep patterns in participants microdosing GLP1s6 months

    Wearable health device data will be monitored over the 24-week period assessing REM vs non-REM sleep and reported as a ratio

  • Change in frequency of physical activity in participants microdosing GLP1s6 months

    The change in frequency of physical activity, defined as a departure from baseline in time spent performing moderate to rigorous physical exercise, will be captured via wearable health device data and will be reported as percent difference from baseline in steps taken.

  • Change in frequency of physical activity in participants microdosing GLP1s6 months

    The change in frequency of physical activity, defined as a departure from baseline in time spent performing moderate to rigorous physical exercise, will be captured via wearable health device data and will be reported as percent difference from baseline in calories burned.