Intranasal LAIV Mucosal Immunity Examination

This study is looking at how the immune system (your body's defense against illness) responds to a nasal spray flu vaccine called Live Attenuated Influenza Vaccine (LAIV). Researchers want to understand why this type of vaccine doesn't cause the same changes in the blood as shots do. They will study immune organs near the nose, like tonsils and adenoids, from people having surgery for sleep apnea. The goal is to see how your body's immune response changes after vaccination by comparing blood tests before and after. This study is for people aged 2 to 89 who are having tonsillectomy and adenoidectomy, and who haven't had this year's flu vaccine. The study is currently unclear on its recruitment status and plans to enroll 25 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment (the nasal spray vaccine). It plans to include 25 participants.
What's involved
You would receive the Live Attenuated Influenza Vaccine (LAIV) nasal spray. Blood tests will be taken before and after vaccination.
Compensation
Not stated in the trial record.
Follow-up
Your immune response will be measured from enrollment up to 4 weeks after your surgery is completed.

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NCT07093281

Intranasal LAIV Mucosal Immunity Examination

Not Yet Recruiting
PHASE4Ages 2–89InterventionalBasic science
University of Maryland, Baltimore
~25 participants
Updated 2025-12-19 on ClinicalTrials.gov
What's tested:Live Attenuated Influenza Vaccine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Serological outcomes will be compared before and after vaccination and between groups.
Measured over From enrollment to 4 weeks after surgery is completed
Impact of Vaccination
1 sites across 1 states
Maryland1

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Eligibility criteria

Inclusion

Patient undergoing tonsillectomy and adenoidectomy as part of the standard of care for sleep apnea

Exclusion

Chronic Tonsillitis
Immune Deficiency
Already received this year's flu vaccine
  • Serological outcomes will be compared before and after vaccination and between groups.From enrollment to 4 weeks after surgery is completed

    The comparisons will specifically compare: Mean HAI Ab titers in serum and mucosal secretions